ArticleAntimicrobial agents and chemotherapy2021
Multiresistance to Nonazole Fungicides in Aspergillus fumigatus TR
Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Identification and characterization of non-canonical azole antifungal resistance pathways inmBio · 2026Article
- Pathogenesis and Triazole Resistance inInfection and drug resistance · 2026Review
- Agricultural SDHIs Induce Azole Resistance in Aspergillus fumigatus via Mitochondrial Sdh1 Suppression.Mycopathologia · 2025Article
- Article
- Moving beyond multi-triazole to multi-fungicide resistance: Broader selection of drug resistance in the human fungal pathogen Aspergillus fumigatus.PLoS pathogens · 2025Article
- Azole resistance in Aspergillus fumigatus- comprehensive review.Archives of microbiology · 2024Review
- Novel antifungals and treatment approaches to tackle resistance and improve outcomes of invasive fungal disease.Clinical microbiology reviews · 2024Review
- Pan-azole- and multi-fungicide-resistantApplied and environmental microbiology · 2024Article
- Importance of theJournal of fungi (Basel, Switzerland) · 2024Article
- The rapid emergence of antifungal-resistant human-pathogenic fungi.Nature reviews. Microbiology · 2023Review
- Occurrence of Aspergillus fumigatus azole resistance in soils from Switzerland.Medical mycology · 2023Article
- Potential Implication of Azole Persistence in the Treatment Failure of Two Haematological Patients Infected withJournal of fungi (Basel, Switzerland) · 2023Article
- Resistance of Black Aspergilli Species from Grape Vineyards to SDHI, QoI, DMI, and Phenylpyrrole Fungicides.Journal of fungi (Basel, Switzerland) · 2023Article
- Evidence for the agricultural origin of resistance to multiple antimicrobials in Aspergillus fumigatus, a fungal pathogen of humans.G3 (Bethesda, Md.) · 2022Article
- Emerging Fungal Infections: from the Fields to the Clinic, ResistantCurrent clinical microbiology reports · 2022Review
- Selection and Amplification of Fungicide Resistance inMicroorganisms · 2021Review
- Epidemiological Studies of Pan-Azole ResistantMicroorganisms · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drug resistance is a worldwide problem affecting all pathogens. The human fungal pathogen Aspergillus fumigatus coexists in the environment with other fungi targeted by crop protection compounds, being unintentionally exposed to the selective pressure of multiple antifungal classes and leading to the selection of resistant strains. A. fumigatus azole-resistant isolates are emerging in both clinical and environmental settings. Since their approval, azole drugs have dominated clinical treatment for aspergillosis infections and the agriculture fungicide market. However, other antifungal classes are used for crop protection, including benzimidazoles (methyl benzimidazole carbamates [MBCs]), strobilurins (quinolone oxidation inhibitors [QoIs]), and succinate dehydrogenase inhibitors (SDHIs). Mutations responsible for resistance to these fungicides have been widely researched in plant pathogens, but resistance has not been explored in A. fumigatus. In this work, the genetic basis underlying resistance to MBCs, QoIs, and SDHIs was studied in azole-susceptible and -resistant A. fumigatus strains. E198A/Q and F200Y mutations in β-tubulin conferred resistance to MBCs, G143A and F129L substitutions in cytochrome
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