ArticleInternational urology and nephrology2021
Regional activity and functional connectivity in brain networks associated with urinary bladder filling in patients with tethered cord syndrome.
Article in International urology and nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Identifying Abnormalities in Regional Brain Activity and Functional Connectivity in Patients With Detrusor Overactivity After Spinal Cord Injury.International neurourology journal · 2026Article
- The impact of transcutaneous tibial nerve stimulation on brain function in patients with overactive bladder: a prospective longitudinal self-controlled study.Frontiers in human neuroscience · 2026Article
- Functional brain imaging and central control of the bladder in health and disease.Frontiers in physiology · 2022Review
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2 authors at 1 institution in 1 country.
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Abstract
purposeAbnormal neural activities can be revealed by resting-state functional magnetic resonance imaging using analyses of regional activity and functional connectivity of brain networks. This study was designed to demonstrate functional network alterations in patients with detrusor overactivity. MATERIALS AND
methodsIn this study, we recruited 36 patients with tethered cord syndrome who had detrusor overactivity and 34 normal controls. We used regional homogeneity and seed-based functional connectivity computational methods to reveal resting-state brain activity features associated with patients.
resultsCompared with normal controls, patients with tethered cord syndrome showed regional abnormalities, mainly in the bilateral frontal cortex, anterior and midcingulate cortex, and temporal lobes. When these regions were defined as seeds, we demonstrated widespread modification in brain networks. The brain-bladder network was not positively connected with the cognitive control network. Both altered regional activity and changed functional connectivity were found in the brain-bladder network.
conclusionPatients with NDO, activated areas in the frontal lobe and anterior cingulate gyrus decreased significantly and have fewer brain activation areas in the caudate nucleus and hypothalamus (limbic system). In functional connectivity work, we found a small positive correlation in different regions of frontal lobe. This study helped us better to understand the characteristics of neural network modifications in patients with tethered cord syndrome.
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