SynthesisJournal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology2021
Arthroscopy versus mini-arthrotomy approach for matrix-induced autologous chondrocyte implantation in the knee: a systematic review.
Synthesis in Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Autologous chondrocyte implantation in the knee is effective in skeletally immature patients: a systematic review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Pooled it
- Cell therapies for chondral defects of the talus: a systematic review.Journal of orthopaedic surgery and research · 2022Pooled it
- Matrix-induced autologous chondrocyte implantation (mACI) versus autologous matrix-induced chondrogenesis (AMIC) for chondral defects of the knee: a systematic review.British medical bulletin · 2022Pooled it
- Trial
- Article
- A Critical Appraisal of Reporting Bias in Systematic Reviews and Meta-Analyses Addressing Knee Chondral Defects.Cartilage · 2025Article
- All-Arthroscopic Membrane Autologous Chondrocyte Implantation for Femoral Cartilage Defects.Arthroscopy techniques · 2025Article
- Review
- Arthroscopic Matrix-Associated Autologous Chondrocyte Implantation for Focal Tibial Defects.Arthroscopy techniques · 2025Article
- Focal Knee Cartilage Defect Treatment With Nanofracture and All-Arthroscopic Autologous Matrix-Induced Chondrogenesis Using Dry Arthroscopy.Arthroscopy techniques · 2025Article
- All-Arthroscopic Matrix-Associated Autologous Chondrocyte Implantation for a Trochlear Defect.Arthroscopy techniques · 2024Article
- Dry Arthroscopic Cartilage Repair of the Knee Joint Using Umbilical Cord Mesenchymal Stem Cells: Kelly Clamp Technique.Arthroscopy techniques · 2023Article
- Platelet rich plasma combined with arthroscopic microfracture versus arthroscopic microfracture alone for the treatment of knee cartilage injury.American journal of translational research · 2023Article
- Fibrin glue does not promote migration and proliferation of bone marrow derived mesenchymal stem cells in collagenic membranes: an in vitro study.Scientific reports · 2022Article
- Minced Cartilage Is a One-Step Cartilage Repair Procedure for Small Defects in the Knee-A Systematic-Review and Meta-Analysis.Journal of personalized medicine · 2022Review
- Fixation of the Membrane during Matrix-Induced Autologous Chondrocyte Implantation in the Knee: A Systematic Review.Life (Basel, Switzerland) · 2022Review
- Fibrin glue does not assist migration and proliferation of chondrocytes in collagenic membranes: an in vitro study.Journal of orthopaedic surgery and research · 2022Article
- Arthroscopic (Arthro) Delivery of MACI (Autologous Cultured Chondrocytes on a Porcine Collagen Membrane) for Defects on Condyles.Video journal of sports medicineArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMatrix-induced autologous chondrocyte implantation (mACI) can be performed in a full arthroscopic or mini-open fashion. A systematic review was conducted to investigate whether arthroscopy provides better surgical outcomes compared with the mini-open approach for mACI in the knee at midterm follow-up.
methodsThis systematic review was conducted following the PRISMA guidelines. The literature search was performed in May 2021. All the prospective studies reporting outcomes after mACI chondral defects of the knee were accessed. Only studies that clearly stated the surgical approach (arthroscopic or mini-open) were included. Only studies reporting a follow-up longer than 12 months were eligible. Studies reporting data from combined surgeries were not eligible, nor were those combining mACI with less committed cells (e.g., mesenchymal stem cells).
resultsSixteen studies were included, and 770 patients were retrieved: 421 in the arthroscopy group, 349 in the mini-open. The mean follow-up was 44.3 (12-60) months. No difference between the two groups was found in terms of mean duration of symptoms, age, body mass index (BMI), gender, defect size (P > 0.1). No difference was found in terms of Tegner Score (P = 0.3), Lysholm Score (P = 0.2), and International Knee Documentation Committee (IKDC) Score (P = 0.1). No difference was found in the rate of failures (P = 0.2) and revisions (P = 0.06).
conclusionArthroscopy and mini-arthrotomy approaches for mACI in knee achieve similar outcomes at midterm follow-up. LEVEL OF EVIDENCE: II, systematic review of prospective studies.
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