ArticleThe Plant cell2021
The Arabidopsis circadian clock protein PRR5 interacts with and stimulates ABI5 to modulate abscisic acid signaling during seed germination.
Article in The Plant cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 89 citations in OpenAlex.
- The EAR motif-containing adaptor protein ECAP enhances ABI5-mediated ABA signaling to inhibit seed germination in Arabidopsis.Plant communications · 2026Article
- SDR3.1 negatively regulates seed dormancy in Poaceae crops.The Plant journal : for cell and molecular biology · 2026Article
- Rewiring the unfolded protein response for plant growth recovery after stress.Plant communications · 2026Review
- Holistic overview of regulatory networks governing seed dormancy and germination in plants.Science China. Life sciences · 2026Review
- OsDi19-1 Acts Downstream of OsABI5 to Negatively Regulate ABA-Inhibited Seed Germination and Seedling Growth in Rice.Rice (New York, N.Y.) · 2026Article
- Genome-wide-association-analysis-based identification of genetic loci and candidate genes associated with seedling emergence rate in super-sweet corn (Zea mays L.).BMC plant biology · 2026Article
- Mediator subunit MED25 represses ABI5-dependent activation of erucic acid biosynthetic geneFrontiers in plant science · 2026Article
- Genome-wide analysis of the CCT gene family in Liriodendron chinense highlights potential functions in light signaling and chlorophyll biosynthesis.BMC plant biology · 2025Article
- ODR1/AtSDR4L alleviates osmotic stress-induced germination arrest via ABA-dependent negative feedback on ABA biosynthesis.BMC plant biology · 2025Article
- CPK2 Enhances ABA Sensitivity in Seed Germination and Root Growth by Promoting ABA-InducedPlants (Basel, Switzerland) · 2025Article
- Transcriptional activation and repression in the plant circadian clock: Revisiting core oscillator feedback loops and output pathways.Plant communications · 2025Review
- Genome-wide identification and characterization of the CCT gene family in Chinese cabbage (Brassica rapa) response to abiotic stress.BMC genomics · 2025Article
- Gamma-aminobutyric acid (GABA) releases seed dormancy by orchestrating abscisic acid and gibberellin metabolism and signaling.BMC plant biology · 2025Article
- Nitrate attenuates abscisic acid signaling via NIN-LIKE PROTEIN8 in Arabidopsis seed germination.The Plant cell · 2025Article
- Revisiting the role of light signaling in plant responses to salt stress.Horticulture research · 2025Article
- From Regulation to Application: The Role of Abscisic Acid in Seed and Fruit Development and Agronomic Production Strategies.International journal of molecular sciences · 2024Review
- Unlocking Nature's Rhythms: Insights into Secondary Metabolite Modulation by the Circadian Clock.International journal of molecular sciences · 2024Review
- A mediator of OsbZIP46 deactivation and degradation negatively regulates seed dormancy in rice.Nature communications · 2024Article
- Pectin methylesterase 31 is transcriptionally repressed by ABI5 to negatively regulate ABA-mediated inhibition of seed germination.Frontiers in plant science · 2024Article
- Regulatory mechanisms of the LBD40 transcription factor inPlant direct · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Seed germination and postgerminative growth require the precise coordination of multiple intrinsic and environmental signals. The phytohormone abscisic acid (ABA) suppresses these processes in Arabidopsis thaliana and the circadian clock contributes to the regulation of ABA signaling. However, the molecular mechanism underlying circadian clock-mediated ABA signaling remains largely unknown. Here, we found that the core circadian clock proteins PSEUDO-RESPONSE REGULATOR5 (PRR5) and PRR7 physically associate with ABSCISIC ACID-INSENSITIVE5 (ABI5), a crucial transcription factor of ABA signaling. PRR5 and PRR7 positively modulate ABA signaling redundantly during seed germination. Disrupting PRR5 and PRR7 simultaneously rendered germinating seeds hyposensitive to ABA, whereas the overexpression of PRR5 enhanced ABA signaling to inhibit seed germination. Consistent with this, the expression of several ABA-responsive genes is upregulated by PRR proteins. Genetic analysis demonstrated that PRR5 promotes ABA signaling mainly dependently on ABI5. Further mechanistic investigation revealed that PRR5 stimulates the transcriptional function of ABI5 without affecting its stability. Collectively, our results indicate that these PRR proteins function synergistically with ABI5 to activate ABA responses during seed germination, thus providing a mechanistic understanding of how ABA signaling and the circadian clock are directly integrated through a transcriptional complex involving ABI5 and central circadian clock components.
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