Evidence map›Paper›PMID 34152029›Full record

ArticleJournal of cutaneous pathology2021

Case report of a clinically indolent but morphologically high-grade cutaneous mast cell tumor in an adult: Atypical cutaneous mastocytoma or mast cell sarcoma?

Claire L W Wardle, J Marja Oldhoff, Arjan Diepstra, Peter Valent, Hans-Peter Horny, Hanneke N G Oude Elberink, Philip M Kluin, Gilles F H Diercks

Open access · hybridAbstract readCase Reports
In one paragraph

Article in Journal of cutaneous pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Claire L W WardleDepartment of Pathology and Medical Biology, University Medical Centre Groningen, Groningen, The Netherlands.
J Marja OldhoffDepartment of Dermatology, University Medical Centre Groningen, Groningen, The Netherlands.
Arjan DiepstraDepartment of Pathology and Medical Biology, University Medical Centre Groningen, Groningen, The Netherlands.
Peter ValentLudwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria.
Hans-Peter HornyInstitute for Pathology, Ludwig-Maximilians University, Munich, Germany.
Hanneke N G Oude ElberinkDepartment of Allergy and Immunology, University Medical Centre Groningen, Groningen, The Netherlands.
Philip M KluinDepartment of Pathology and Medical Biology, University Medical Centre Groningen, Groningen, The Netherlands.
Gilles F H DiercksDepartment of Pathology and Medical Biology, University Medical Centre Groningen, Groningen, The Netherlands.ORCID https://orcid.org/0000-0001-8053-216X
University Medical Center Groningen · NLLudwig-Maximilians-Universität München · DEMedical University of Vienna · AT

Funding

Austrian Science Fund (FWF) F4704-B20Austrian Science Fund (FWF) P32470-BAustrian Science Fund FWF P 32470
6 · The paper itself

Abstract

We present a case of an adult male with a solitary mast cell tumor of the skin with unusual nuclear pleomorphism and mitotic activity. The tumor was excised, recurred within 2 years, was reexcised after 4 years and did not recur >6 years after diagnosis. The tumor showed progressive cytonuclear atypia and a high mitotic and proliferation rate by Ki67-staining from the onset. No KIT mutations were identified in the tumor and bone marrow. Serum tryptase levels and a bone marrow aspirate and trephine biopsy were normal. Although the histomorphology of the skin tumor was consistent with mast cell sarcoma, the clinical behavior without systemic progression argued against this diagnosis. The tumor was finally considered as atypical mastocytoma, borderline to mast cell sarcoma. Currently, the patient is in close follow-up and still in complete remission.

Indexed as

AdultDiagnosis, DifferentialHumansMaleMast-Cell SarcomaMastocytoma, Skinadultcase reportsmast-cell sarcomamastocytomamastocytosis

Identifiers

PMID34152029
PMCPMC8638666
OpenAlexW3175161421

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.