Evidence map›Paper›PMID 34151973›Full record

Trial reportInternational journal of epidemiology2022

Effects of prenatal and postnatal maternal multiple micronutrient supplementation on child growth and morbidity in Tanzania: a double-blind, randomized-controlled trial.

Dongqing Wang, Uma Chandra Mouli Natchu, Anne Marie Darling, Ramadhani A Noor, Ellen Hertzmark, Willy Urassa, Wafaie W Fawzi

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 3 pooled it
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 syntheses or guidelines pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. The culture of experimentation in epidemiology-50 years later.International journal of epidemiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Dongqing WangDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Uma Chandra Mouli NatchuDivision of Infectious Diseases, St. John's Research Institute, Bengaluru, India.
Anne Marie DarlingDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Ramadhani A NoorUnited Nations Children's Fund Tanzania, Dar es Salaam, Tanzania.
Ellen HertzmarkDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Willy UrassaDepartment of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Wafaie W FawziDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Harvard Global Health Institute · USHarvard University · USMuhimbili University of Health and Allied Sciences · TZWWF Tanzania · TZ

Funding

A TRAIL OF MICRONUTRIENTS AND ADVERSE PREGNANCY OUTCOMESR01HD037701 · NICHD · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI FAWZI, WAFAIE W · 2000 to 2003
$3.8M
6 · The paper itself

Abstract

backgroundMaternal micronutrient status is critical for child growth and nutrition. It is unclear whether maternal multiple micronutrient supplementation (MMS) during pregnancy and lactation improves child growth and prevents child morbidity.

methodsThis study aimed to determine the effects of prenatal and postnatal maternal MMS on child growth and morbidity. In this double-blind, randomized-controlled trial, 8428 HIV-negative pregnant women were enrolled from Dar es Salaam, Tanzania, between 2001 and 2004. From pregnancy (12-27 weeks of gestation) through to 6 weeks postpartum, participants were randomized to receive daily oral MMS or placebo. All women received daily iron and folic acid during pregnancy. From 6 weeks postpartum through to 18 months postpartum, 3100 women were re-randomized to MMS or placebo. Child-growth measures, haemoglobin concentrations and infectious morbidities were assessed longitudinally from birth to ≤18 months.

resultsPrenatal MMS led to modest increases in weight-for-age z-scores (mean difference: 0.050; 95% confidence interval: 0.002, 0.099; p = 0.04) and length-for-age z-score (mean difference: 0.062; 95% confidence interval: 0.013, 0.111; p = 0.01) during the first 6 months of life but not thereafter. Prenatal or postnatal MMS did not have benefits for other child outcomes.

conclusionsWhereas maternal MMS is a proven strategy to prevent adverse birth outcomes, other approaches may also need to be considered to curb the high burdens of child morbidity and growth faltering.

Indexed as

Dietary SupplementsVitaminsDouble-Blind MethodFemaleFolic AcidHumansMicronutrientsMorbidityPregnancyTanzaniaFolic AcidMicronutrientsVitaminsanaemialactationmicronutrientspostpartumPregnancysupplementationTanzaniavitaminwomen

Identifiers

PMID34151973
PMCPMC9749718
OpenAlexW3175550952

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.