Evidence map›Paper›PMID 34151803›Full record

ArticleJournal of Alzheimer's disease : JAD2021

Central Obesity, Cardiometabolic Risk, and Cognitive Change in the Study of Latinos - Investigation of Neurocognitive Aging.

Ariana M Stickel, Wassim Tarraf, Kevin A Gonzalez, Carmen R Isasi, Robert Kaplan, Linda C Gallo, Donglin Zeng, Jianwen Cai, Amber Pirzada, Martha L Daviglus and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Observational
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Ariana M StickelDepartment of Neurosciences and Shiley-Marcos Alzheimer's Disease Research Center, University of California, San Diego, La Jolla, CA, USA.
Wassim TarrafInstitute of Gerontology & Department of Healthcare Sciences, Wayne State University, Detroit, MI, USA.
Kevin A GonzalezDepartment of Neurosciences and Shiley-Marcos Alzheimer's Disease Research Center, University of California, San Diego, La Jolla, CA, USA.
Carmen R IsasiDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Robert KaplanDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Linda C GalloDepartment of Psychology, San Diego State University, San Diego, CA, USA.
Donglin ZengDepartment of Biostatistics, University of North Carolina, Chapel Hill, NC, USA.
Jianwen CaiDepartment of Biostatistics, University of North Carolina, Chapel Hill, NC, USA.
Amber PirzadaInstitute for Minority Health Research, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA.
Martha L DaviglusInstitute for Minority Health Research, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA.
Zachary T GoodmanDepartment of Psychology, University of Miami, Miami, FL, USA.
Neil SchneidermanDepartment of Psychology, University of Miami, Miami, FL, USA.
Hector M GonzálezDepartment of Neurosciences and Shiley-Marcos Alzheimer's Disease Research Center, University of California, San Diego, La Jolla, CA, USA.
University of California, San Diego · USAlbert Einstein College of Medicine · USUniversity of Illinois Chicago · USUniversity of Miami · USUniversity of North Carolina at Chapel Hill · USSan Diego State University · USWayne State University · US

Funding

UCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Mark W Bondi · 2019 to 2026
$34.9M
MRI Measures of Cerebrovascular Injury and AD Atrophy in a Study of LatinosRF1AG054548 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DECARLI, CHARLES, GONZALEZ, HECTOR M · 2017 to 2017
$14.7M
San Diego Resource Center for advancing Alzheimer's Research in Minority Seniors (ARMS)P30AG059299 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Tala Al-Rousan · 2018 to 2026
$7.4M
Neurocognitive aging, MCI and Alzheimer's disease DNA methylation among diverse LatinosRF1AG061022 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FORNAGE, MYRIAM, GONZALEZ, HECTOR M · 2019 to 2019
$6.6M
Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA)R01AG048642 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GONZALEZ, HECTOR M · 2015 to 2019
$5.7M
Risk Factors for Alzheimer's Disease Among Latinos: Relationships Between Cardiovascular Disease Risk, Acculturation, Small Vessel Disease, and Alzheimer's BiomarkersK08AG075351 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ariana Stickel · 2022 to 2026
$770k
HISPANIC COMMUNITY HEALTH STUDY-268065233N01HC065233 · HC · COORDINATING CENTER · PI CHAMBLESS, LLOYD E · 2006 to 2006
–
NHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NIA NIH HHS K08 AG075351NIA NIH HHS L30 AG074401NIA NIH HHS P30 AG059299NIA NIH HHS P30 AG062429NIA NIH HHS R01 AG048642NIA NIH HHS RF1 AG054548NIA NIH HHS RF1 AG061022
6 · The paper itself

Abstract

backgroundThe relationships between obesity and cognitive decline in aging are mixed and understudied among Hispanics/Latinos.

objectiveTo understand associations between central obesity, cognitive aging, and the role of concomitant cardiometabolic abnormalities among Hispanics/Latinos.

methodsParticipants included 6,377 diverse Hispanics/Latinos enrolled in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) and SOL-Investigation for Neurocognitive Aging (SOL-INCA). Participants were 45 years and older at the first cognitive testing session (Visit 1). Cognitive outcomes (z-score units) included global composite and domain specific (learning, memory, executive functioning, processing speed) measures at a second visit (SOL-INCA, on average, 7 years later), and 7-year change. We used survey linear regression to examine associations between central obesity (waist circumference≥88 cm and≥102 cm for women and men, respectively) and cognition. We also tested whether the relationships between obesity and cognition differed by cardiometabolic status (indication of/treatment for 2 + of the following: high triglycerides, hypertension, hyperglycemia, low high-density lipoprotein cholesterol).

resultsCentral obesity was largely unassociated with cognitive outcomes, adjusting for covariates. However, among individuals with central obesity, cardiometabolic abnormality was linked to poorer cognitive function at SOL-INCA (ΔGlobalCognition =-0.165, p < 0.001) and to more pronounced cognitive declines over the average 7 years (ΔGlobalCognition = -0.109, p < 0.05); this was consistent across cognitive domains.

conclusionCentral obesity alone was not associated with cognitive function. However, presence of both central obesity and cardiometabolic abnormalities was robustly predictive of cognition and 7-year cognitive declines, suggesting that in combination these factors may alter the cognitive trajectories of middle-aged and older Hispanics/Latinos.

Indexed as

Cardiometabolic Risk FactorsHispanic or LatinoNeuropsychological TestsAgedAged, 80 and overAgingCognitive AgingCognitive DysfunctionCohort StudiesFemaleHumansMaleMiddle AgedObesity, AbdominalProspective StudiesAgingcardiometabolic risk factorscognitiondiabetes mellitusHispanicshyperlipidemiashypertensionLatinosobesity

Identifiers

PMID34151803
PMCPMC10792520
OpenAlexW3170176366

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.