ArticleeLife2021
Stability of neocortical synapses across sleep and wake states during the critical period in rats.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Frontal synaptic plasticity: A new key to homeostatic sleep regulation.Neural regeneration research · 2026Article
- Unbiased Segmentation and Multifeature Classification of Cortical Neuronal Activity Reveals Complex Dynamics Under Anesthesia.Neuroscience bulletin · 2026Article
- Latent mechanisms of plasticity are upregulated during sleep.Current opinion in neurobiology · 2025Review
- Preoptic area influences sleep-related seizures in a genetic epilepsy mouse model.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Rapid prey capture learning drives a slow resetting of network activity in rodent binocular visual cortex.bioRxiv : the preprint server for biology · 2025Article
- Dynamics of evoked responses in hippocampal pathways are encoded by the duration of vigilance states.Nature communications · 2025Article
- Modular Arrangement of Synaptic and Intrinsic Homeostatic Plasticity within Visual Cortical Circuits.bioRxiv : the preprint server for biology · 2025Article
- Developing forebrain synapses are uniquely vulnerable to sleep loss.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Visual Deprivation during Mouse Critical Period Reorganizes Network-Level Functional Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Automatic sleep-wake classification and Parkinson's disease recognition using multifeature fusion with support vector machine.CNS neuroscience & therapeutics · 2024Article
- Basal forebrain cholinergic activity is necessary for upward firing rate homeostasis in the rodent visual cortex.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Evidence that Alzheimer's Disease Is a Disease of Competitive Synaptic Plasticity Gone Awry.Journal of Alzheimer's disease : JAD · 2024Review
- GABAergic synaptic transmission and plasticity oscillate across sleep and wake.Neural regeneration research · 2023Article
- Article
- Synapse-Specific Modulation of Synaptic Responses by Brain States in Hippocampal Pathways.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Remembering and forgetting in sleep: Selective synaptic plasticity during sleep driven by scaling factors Homer1a and Arc.Neurobiology of stress · 2023Article
- Sleep and wake cycles dynamically modulate hippocampal inhibitory synaptic plasticity.PLoS biology · 2022Article
- Strong Aversive Conditioning Triggers a Long-Lasting Generalized Aversion.Frontiers in cellular neuroscience · 2022Article
- Sleep promotes the formation of dendritic filopodia and spines near learning-inactive existing spines.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Homeostatic synaptic scaling establishes the specificity of an associative memory.Current biology : CB · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Sleep is important for brain plasticity, but its exact function remains mysterious. An influential but controversial idea is that a crucial function of sleep is to drive widespread downscaling of excitatory synaptic strengths. Here, we used real-time sleep classification, ex vivo measurements of postsynaptic strength, and in vivo optogenetic monitoring of thalamocortical synaptic efficacy to ask whether sleep and wake states can constitutively drive changes in synaptic strength within the neocortex of juvenile rats. We found that miniature excitatory postsynaptic current amplitudes onto L4 and L2/3 pyramidal neurons were stable across sleep- and wake-dense epochs in both primary visual (V1) and prefrontal cortex (PFC). Further, chronic monitoring of thalamocortical synaptic efficacy in V1 of freely behaving animals revealed stable responses across even prolonged periods of natural sleep and wake. Together, these data demonstrate that sleep does not drive widespread downscaling of synaptic strengths during the highly plastic critical period in juvenile animals. Whether this remarkable stability across sleep and wake generalizes to the fully mature nervous system remains to be seen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.