Evidence map›Paper›PMID 34151666›Full record

ReviewCritical reviews in biochemistry and molecular biology2021

The leucine-responsive regulatory proteins/feast-famine regulatory proteins: an ancient and complex class of transcriptional regulators in bacteria and archaea.

Christine A Ziegler, Peter L Freddolino

Open access · greenAbstract readReviewVideo-Audio Media
In one paragraph

Review in Critical reviews in biochemistry and molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 43 citations in OpenAlex.

  1. Loss of CsrA inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. BldDss Modulates the Functional Role ofJournal of agricultural and food chemistry · 2026
    Article
  7. The Algorithm for Reversible Jump Inference of Motifs.bioRxiv : the preprint server for biology · 2025
    Article
  8. Review
  9. A regulator of amino acid catabolism controlsbioRxiv : the preprint server for biology · 2025
    Article
  10. Nucleoid-associated proteins: molecular mechanisms in microbial adaptation.World journal of microbiology & biotechnology · 2025
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Christine A ZieglerDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI, USA.
Peter L FreddolinoDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0002-5821-4226
University of Michigan · US

Funding

PREDOCTORAL TRAINING IN GENETICST32GM007544 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MORAN, JOHN V. · 1985 to 2022
$11.3M
Building a unified framework for understanding bacterial gene regulation and chromosomal architectureR35GM128637 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lydia Petra Freddolino · 2018 to 2026
$3.6M
NIGMS NIH HHS R35 GM128637NIGMS NIH HHS T32 GM007544
6 · The paper itself

Abstract

Since the discovery of the

Indexed as

ArchaeaArchaeal ProteinsEscherichia coliEscherichia coli ProteinsLeucine-Responsive Regulatory ProteinArchaeal ProteinsEscherichia coli ProteinsLeucine-Responsive Regulatory ProteinLrp protein, E colifeast-famine response proteinsglobal regulatorleucine-responsive regulatory proteinLrpsystems biology

Identifiers

PMID34151666
PMCPMC9239533
OpenAlexW3173769734

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.