Evidence map›Paper›PMID 34151590›Full record

ArticleAmerican journal of physiology. Renal physiology2021

Differential localization patterns of claudin 10, 16, and 19 in human, mouse, and rat renal tubular epithelia.

Caroline Prot-Bertoye, Camille Griveau, Karsten Skjødt, Lydie Cheval, Gaëlle Brideau, Loïc Lievre, Elsa Ferriere, Floriane Arbaretaz, Kevin Garbin, Reza Zamani and 7 more

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Claudin-3 is expressed at theFrontiers in physiology · 2026
    Article
  6. Control of renal calcium permeability via a tight junctional claudin switch.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. Calcium-Sensing Receptor in the Thick Ascending Limb and Renal Response to Hypercalcemia.Journal of the American Society of Nephrology : JASN · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Impact of claudin-10 deficiency on amelogenesis: Lesson from a HELIX tooth.Annals of the New York Academy of Sciences · 2022
    Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 3 countries.

Caroline Prot-BertoyeCentre de Recherche des Cordeliers, Institut National de la Santé et de la Recherche Médicale, Sorbonne Université, Université de Paris, Paris, France.
Camille GriveauCentre de Recherche des Cordeliers, Institut National de la Santé et de la Recherche Médicale, Sorbonne Université, Université de Paris, Paris, France.
Karsten SkjødtDepartment of Cancer and Inflammation, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Lydie ChevalCentre de Recherche des Cordeliers, Institut National de la Santé et de la Recherche Médicale, Sorbonne Université, Université de Paris, Paris, France.
Gaëlle BrideauCentre de Recherche des Cordeliers, Institut National de la Santé et de la Recherche Médicale, Sorbonne Université, Université de Paris, Paris, France.
Loïc LievreCentre de Recherche des Cordeliers, Institut National de la Santé et de la Recherche Médicale, Sorbonne Université, Université de Paris, Paris, France.
Elsa FerriereCentre de Recherche des Cordeliers, Institut National de la Santé et de la Recherche Médicale, Sorbonne Université, Université de Paris, Paris, France.
Floriane ArbaretazCentre d'Histologie, d'Imagerie et de Cytométrie, Centre de Recherche des Cordeliers, Institut National de la Santé et de la Recherche Médicale, Sorbonne Université, Université de Paris, Paris, France.
Kevin GarbinCentre d'Histologie, d'Imagerie et de Cytométrie, Centre de Recherche des Cordeliers, Institut National de la Santé et de la Recherche Médicale, Sorbonne Université, Université de Paris, Paris, France.
Reza ZamaniDepartment of Urology, Odense University Hospital, Odense, Denmark.
Niels MarcussenDepartment of Clinical Pathology, Odense University Hospital, Odense, Denmark.
Lucile FigueresCentre de Recherche des Cordeliers, Institut National de la Santé et de la Recherche Médicale, Sorbonne Université, Université de Paris, Paris, France.
Tilman BreiderhoffDivision of Gastroenterology, Nephrology and Metabolic Diseases, Department of Pediatrics, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Dominik MullerDivision of Gastroenterology, Nephrology and Metabolic Diseases, Department of Pediatrics, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Patrick BrunevalAssistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service d'Anatomopathologie, Paris, France.
Pascal HouillierCentre de Recherche des Cordeliers, Institut National de la Santé et de la Recherche Médicale, Sorbonne Université, Université de Paris, Paris, France.
Henrik DimkeDepartment of Cardiovascular and Renal Research, University of Southern Denmark, Odense, Denmark.ORCID 0000-0002-9170-2168
Centre National de la Recherche Scientifique · FRCharité - Universitätsmedizin Berlin · DEInserm · FROdense University Hospital · DKUniversity of Southern Denmark · DKAssistance Publique – Hôpitaux de Paris · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Functional properties of the paracellular pathway depend critically on the set of claudins (CLDN) expressed at the tight junction. Two syndromes are causally linked to loss-of-function mutations of claudins: hypohidrosis, electrolyte imbalance, lacrimal gland dysfunction, ichthyosis, and xerostomia (HELIX) syndrome caused by genetic variations in the

Indexed as

AnimalsClaudinsEpitheliumHumansImmunohistochemistryKidney TubulesMiceRatsTight Junctionsclaudin 10claudin 16ClaudinsCLDN19 protein, humanepitheliumimmunolocalizationkidneythick ascending limbtight junction

Identifiers

PMID34151590
PMCPMC8424667
OpenAlexW3173957393

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.