Evidence map›Paper›PMID 34151527›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021

Discretizing Three-Dimensional Oxygen Gradients to Modulate and Investigate Cellular Processes.

Michael R Blatchley, Franklyn Hall, Dimitris Ntekoumes, Hyunwoo Cho, Vidur Kailash, Rafael Vazquez-Duhalt, Sharon Gerecht

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Acute Three-Dimensional Hypoxia Regulates Angiogenesis.Advanced healthcare materials · 2025
    Article
  3. Review
  4. Article
  5. The extracellular matrix mechanics in the vasculature.Nature cardiovascular research · 2023
    Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Michael R BlatchleyDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.
Franklyn HallDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.
Dimitris NtekoumesDepartment of Chemical and Biomolecular Engineering, Institute for NanoBioTechnology and Johns Hopkins Physical Sciences-Oncology Center, Johns Hopkins University, Baltimore, MD, 21218, USA.
Hyunwoo ChoDepartment of Chemical and Biomolecular Engineering, Institute for NanoBioTechnology and Johns Hopkins Physical Sciences-Oncology Center, Johns Hopkins University, Baltimore, MD, 21218, USA.
Vidur KailashDepartment of Biophysics, Johns Hopkins University, Baltimore, MD, 21218, USA.
Rafael Vazquez-DuhaltDepartment of Bionanotechnology, Center for Nanosciences and Nanotechnology, National Autonomous University of Mexico, Ensenada, Baja California, 22800, Mexico.
Sharon GerechtDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.ORCID 0000-0002-8542-4835
Johns Hopkins University · USUniversidad Nacional Autónoma de México · MX

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI WILLIAM George NELSON · 1985 to 2026
$208.6M
BIOMEDICAL ENGINEERING TRAINING PROGRAMT32GM007057 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI KANOLD, PATRICK O, KARCHIN, RACHEL · 1985 to 2023
$10.4M
The Role of Physical Cues in Collective Cell InvasionU54CA210173 · NCI · JOHNS HOPKINS UNIVERSITY · PI PIENTA, KENNETH J., WIRTZ, DENIS · 2016 to 2020
$9.9M
Elucidating a mechanism for hypoxic cluster-based vasculogenesisF31HL137339 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI BLATCHLEY, MICHAEL · 2017 to 2019
$93k
Air Force Office of Scientific Research FA9550-20-1-0356NCI NIH HHS P30 CA006973NCI NIH HHS U54 CA210173NCI Physical Sciences Oncology Center U54CA210173NHLBI NIH HHS F31 HL137339NIGMS NIH HHS T32 GM007057
6 · The paper itself

Abstract

With the increased realization of the effect of oxygen (O

Indexed as

Biomimetic MaterialsCell CommunicationCell EngineeringCell SurvivalCellular MicroenvironmentExtracellular MatrixHumansHydrogelsHypoxiaModels, BiologicalOxygenHydrogelsOxygencell survivalhydrogelshypoxiaoxidative stressvasculogenesis

Identifiers

PMID34151527
PMCPMC8292886
OpenAlexW3173932077

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.