ArticleiScience2021
Age-related central gain compensation for reduced auditory nerve output for people with normal audiograms, with and without tinnitus.
Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Effects of age and noise exposure history on auditory nerve response amplitudes: A systematic review, study, and meta-analysis.Hearing research · 2024Pooled it
- Age-related auditory nerve deficits propagate central gain throughout the auditory system: Associations with cortical microstructure and speech recognition.Neurobiology of aging · 2026Article
- Age-related differences in GABAergic synapses across the central inferior colliculus in the Fischer Brown Norway rat.Neurobiology of aging · 2025Article
- The daily auditory environments of people with tinnitus.Scientific reports · 2025Article
- Altered auditory brainstem responses are post-acute sequela of SARS-CoV-2 (PASC).Scientific reports · 2025Article
- Article
- Resistance to age-related hearing loss in the echolocating big brown bat (Proceedings. Biological sciences · 2024Article
- Hypoactivation of the central auditory system in listeners who are hypertolerant of background noise.Journal of neurophysiology · 2024Article
- Neurometric amplitude modulation detection in the inferior colliculus of Young and Aged rats.Hearing research · 2024Article
- Attention-Modulated Cortical Responses as a Biomarker for Tinnitus.Brain sciences · 2024Article
- Female GluA3-KO mice show early onset hearing loss and afferent swellings in ambient sound levels.bioRxiv : the preprint server for biology · 2024Article
- Effects of Age and Noise Exposure History on Auditory Nerve Response Amplitudes: A Systematic Review, Study, and Meta-Analysis.bioRxiv : the preprint server for biology · 2024Article
- Comprehensive behavioral and physiologic assessment of peripheral and central auditory function in individuals with mild traumatic brain injury.Hearing research · 2024Article
- Objective Detection of Tinnitus Based on Electrophysiology.Brain sciences · 2022Review
- The Relative Contribution of Cochlear Synaptopathy and Reduced Inhibition to Age-Related Hearing Impairment for People With Normal Audiograms.Trends in hearingArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Central gain compensation for reduced auditory nerve output has been hypothesized as a mechanism for tinnitus with a normal audiogram. Here, we investigate if gain compensation occurs with aging. For 94 people (aged 12-68 years, 64 women, 7 tinnitus) with normal or close-to-normal audiograms, the amplitude of wave I of the auditory brainstem response decreased with increasing age but was not correlated with wave V amplitude after accounting for age-related subclinical hearing loss and cochlear damage, a result indicative of age-related gain compensation. The correlations between age and wave I/III or III/V amplitude ratios suggested that compensation occurs at the wave III generator site. For each one of the seven participants with non-pulsatile tinnitus, the amplitude of wave I, wave V, and the wave I/V amplitude ratio were well within the confidence limits of the non-tinnitus participants. We conclude that increased central gain occurs with aging and is not specific to tinnitus.
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