Evidence map›Paper›PMID 34151207›Full record

ArticleACS pharmacology & translational science2021

Functional Selectivity of a Biased Cannabinoid-1 Receptor (CB

Ziyi Liu, Malliga R Iyer, Grzegorz Godlewski, Tony Jourdan, Jie Liu, Nathan J Coffey, Charles N Zawatsky, Henry L Puhl, Jürgen Wess, Jaroslawna Meister and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in ACS pharmacology & translational science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 56 citations in OpenAlex.

  1. Side-Chain Homologs of ΔMolecular neurobiology · 2026
    Article
  2. Review
  3. The evolving landscape of obesity pharmacotherapy.Nature reviews. Drug discovery · 2026
    Review
  4. Article
  5. Article
  6. CBMolecular psychiatry · 2026
    Article
  7. Article
  8. Elucidating biased signaling in class A GPCRs.Trends in pharmacological sciences · 2025
    Review
  9. Article
  10. Hepatic CB1 receptor signaling triggers GMetabolism: clinical and experimental · 2025
    Article
  11. Article
  12. Structural mechanism of CBNature communications · 2024
    Article
  13. Review
  14. Article
  15. Article
  16. Pharmacological Evaluation of Cannabinoid Receptor Modulators Using GRABInternational journal of molecular sciences · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. G protein-coupled receptors and obesity.Frontiers in endocrinology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Ziyi LiuLaboratory of Physiologic Studies and Section on Cellular Biophotonics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892-9304, United States.
Malliga R IyerLaboratory of Physiologic Studies and Section on Cellular Biophotonics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892-9304, United States.ORCID 0000-0002-0116-4619
Grzegorz GodlewskiLaboratory of Physiologic Studies and Section on Cellular Biophotonics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892-9304, United States.
Tony JourdanLaboratory of Physiologic Studies and Section on Cellular Biophotonics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892-9304, United States.
Jie LiuLaboratory of Physiologic Studies and Section on Cellular Biophotonics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892-9304, United States.
Nathan J CoffeyLaboratory of Physiologic Studies and Section on Cellular Biophotonics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892-9304, United States.
Charles N ZawatskyLaboratory of Physiologic Studies and Section on Cellular Biophotonics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892-9304, United States.
Henry L PuhlLaboratory of Physiologic Studies and Section on Cellular Biophotonics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892-9304, United States.
Jürgen WessLaboratory of Bioorganic Chemistry, National Institute on Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland 20892-0001, United States.
Jaroslawna MeisterLaboratory of Bioorganic Chemistry, National Institute on Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland 20892-0001, United States.
Jeih-San LiowMolecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892-9663, United States.
Robert B InnisMolecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892-9663, United States.
Sergio A HassanBioinformatics and Computational Biosciences Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States.ORCID 0000-0003-3319-078X
Yong Sok LeeBioinformatics and Computational Biosciences Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States.ORCID 0000-0002-6222-1197
George KunosLaboratory of Physiologic Studies and Section on Cellular Biophotonics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892-9304, United States.
Resat CinarLaboratory of Physiologic Studies and Section on Cellular Biophotonics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892-9304, United States.ORCID 0000-0002-8597-7253
National Institute on Alcohol Abuse and Alcoholism · USNational Institute of Diabetes and Digestive and Kidney Diseases · USNational Institute of Mental Health · USNational Institutes of Health · US

Funding

Translational Evaluation Of PET RadiotracersZIAMH002795 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI INNIS, ROBERT · 2009 to 2025
$32.0M
Endocannabinoids And Energy HomeostasisZIAAA000350 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI KUNOS, GEORGE · 2009 to 2025
$28.4M
Fibroproliferative mechanisms in organ fibrosisZIAAA000355 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI CINAR, RESAT · 2021 to 2025
$6.6M
Novel Cannabinoid Receptor ModulatorsZIAAA000360 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI IYER, MALLIGA · 2021 to 2025
$5.9M
6 · The paper itself

Abstract

Seven-transmembrane receptors signal via G-protein- and β-arrestin-dependent pathways. We describe a peripheral CB

Identifiers

PMID34151207
PMCPMC8204328
OpenAlexW3149782815

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.