Evidence map›Paper›PMID 34151204›Full record

ArticleACS pharmacology & translational science2021

Inhibition of Histone Deacetylases 1, 2, and 3 Enhances Clearance of Cholesterol Accumulation in Niemann-Pick C1 Fibroblasts.

Dana L Cruz, Nina Pipalia, Shu Mao, Deepti Gadi, Gang Liu, Michael Grigalunas, Matthew O'Neill, Taylor R Quinn, Andi Kipper, Andreas Ekebergh and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS pharmacology & translational science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 2 countries.

Dana L CruzDepartment of Biochemistry, Weill Cornell Medical College, New York, New York 10065, United States.ORCID https://orcid.org/0000-0003-4793-7696
Nina PipaliaDepartment of Biochemistry, Weill Cornell Medical College, New York, New York 10065, United States.
Shu MaoDepartment of Biochemistry, Weill Cornell Medical College, New York, New York 10065, United States.
Deepti GadiDepartment of Biochemistry, Weill Cornell Medical College, New York, New York 10065, United States.
Gang LiuDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Michael GrigalunasDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Matthew O'NeillDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Taylor R QuinnDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Andi KipperDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Andreas EkeberghDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.ORCID https://orcid.org/0000-0003-3047-4699
Alexander DimmlingDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Carlos GartnerDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Bruce J MelanconDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Florence F WagnerEli and Edythe L. Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
Edward HolsonEli and Edythe L. Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
Paul HelquistDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.ORCID https://orcid.org/0000-0003-4380-9566
Olaf WiestDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.ORCID https://orcid.org/0000-0001-9316-7720
Frederick R MaxfieldDepartment of Biochemistry, Weill Cornell Medical College, New York, New York 10065, United States.ORCID https://orcid.org/0000-0003-4396-8866
University of Notre Dame · USCornell University · USBroad Institute · US

Funding

Chemistry-Biochemistry-Biology Training Program at Notre DameT32GM075762 · NIGMS · UNIVERSITY OF NOTRE DAME · PI CHANG, MAYLAND F, MOBASHERY, SHAHRIAR · 2007 to 2021
$3.7M
Histone Deacetylase Inhibitors for Treatment of Niemann-Pick C1 DiseaseR01NS092653 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI MAXFIELD, FREDERICK R., WALKLEY, STEVEN UPSHAW · 2015 to 2019
$2.8M
NIGMS NIH HHS T32 GM075762NINDS NIH HHS R01 NS092653
6 · The paper itself

Abstract

Niemann-Pick disease type C1 (NPC1) is a rare genetic cholesterol storage disorder caused by mutations in the

Identifiers

PMID34151204
PMCPMC8204796
OpenAlexW3172759631

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.