ArticleTranslational animal science2021
Efficacy of oral meloxicam as primary pain mitigation following caustic paste disbudding of three day old Holstein calves
Article in Translational animal science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Substance P concentrations in the blood plasma and serum of adult cattle and calves during different painful procedures and conditions - a systematic review.BMC veterinary research · 2022Pooled it
- Influence of a repeated peripheral electrical stimulation on substance P and cortisol concentrations, and behavior in German Simmental calves - a pilot study.Frontiers in veterinary science · 2026Article
- Biotinidase as a novel biomarker for pain assessment in dairy cattle.Pain reports · 2025Article
- Comparison of plasma substance P concentrations in the blood of healthy male and female German Simmental calves.BMC veterinary research · 2024Article
- Pain pathophysiology and pharmacology of cattle: how improved understanding can enhance pain prevention, mitigation, and welfare.Frontiers in pain research (Lausanne, Switzerland) · 2024Review
- Evaluation of Substance P concentrations in the blood plasma of jugular and tail vein of healthy German Simmental cows.BMC veterinary research · 2023Article
- Literature Review on Technological Applications to Monitor and Evaluate Calves' Health and Welfare.Animals : an open access journal from MDPI · 2023Review
- A Clinical Trial on the Welfare Effects of Administering Meloxicam to 10 to 21 Day Dairy Calves Following Caustic Paste Disbudding.Journal of animal science · 2023Article
- Methods for Pain Assessment in Calves and Their Use for the Evaluation of Pain during Different Procedures-A Review.Animals : an open access journal from MDPI · 2021Review
- Evaluation of an herbal therapy to alleviate acute pain and stress of disbudded dairy calves under organic management.Translational animal science · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to investigate the effects of perioperative administration of oral meloxicam prior to and following the application of caustic paste to disbud neonatal dairy calves. Sixty-one 3-4-d-old Holstein heifer calves were randomly assigned to one of four treatment groups of 15-16 calves. The treatment groups were: 1) M1, caustic paste disbudding and oral meloxicam (45 mg) with a placebo 24 h later; 2) M2, treatment M1 followed by a second 45-mg dose of meloxicam 24 h later instead of placebo; 3) CONTROL, treatment M1 with placebo in place of meloxicam; and 4) SHAM, sham disbudding with placebo in place of meloxicam. Infrared thermography was used to quantify eye and horn bud temperatures. Pressure algometry was used to measure Mechanical nociceptive threshold (MNT) surrounding the horn bud. Average daily gain and body weight (BW) were obtained by weighing each animal throughout the study and calculating the changes over time. Plasma was collected and analyzed for cortisol and substance P concentrations. Substance P and cortisol decreased in all animals over time, regardless of treatment. Mean plasma substance P concentration across all time points was greater (
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Registered trials
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