Evidence map›Paper›PMID 34151053›Full record

ArticleCurrent opinion in biomedical engineering2021

Musculoskeletal Microbiology: The Microbiome in Orthopaedic Biomechanics.

Christopher J Hernandez

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current opinion in biomedical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06951477 (Gut Microbiome in Orthopaedics), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06951477 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Gut Microbiome in Orthopaedics: Investigating the Role of Gut Microbiome Composition in Total Knee Arthroplasty Failure

TypeobservationalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2025 to 2027Enrolled30ConditionsRevision Total Knee Arthroplasty, Osteoarthritis, KneeArmsRevision Total Knee Arthroplasty
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Christopher J HernandezSibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, USA.
Cornell University · US

Funding

The Microbiome and Bone StrengthR01AG067997 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HERNANDEZ, CHRISTOPHER JOHN · 2021 to 2025
$3.2M
The Microbiome and Bone StrengthR56AG067997 · NIA · CORNELL UNIVERSITY · PI HERNANDEZ, CHRISTOPHER JOHN · 2020 to 2020
$597k
The Role of Bone Resorption in Bone Marrow LesionsR21AR073454 · NIAMS · CORNELL UNIVERSITY · PI HERNANDEZ, CHRISTOPHER JOHN · 2018 to 2019
$407k
Separating Systemic Inflammation From Obesity in Load-Induced OsteoarthritisR21AR068061 · NIAMS · CORNELL UNIVERSITY · PI HERNANDEZ, CHRISTOPHER JOHN · 2015 to 2016
$371k
Associations between gut microbiota, flagellin production and bone microstructureF33AR065348 · NIAMS · CORNELL UNIVERSITY · PI HERNANDEZ, CHRISTOPHER JOHN · 2013 to 2013
$51k
NIAMS NIH HHS F33 AR065348NIAMS NIH HHS R21 AR068061NIAMS NIH HHS R21 AR073454NIA NIH HHS R01 AG067997NIA NIH HHS R56 AG067997
6 · The paper itself

Abstract

Orthopaedic biomechanics and bioengineering is a founding discipline of biomedical engineering that focuses on the effects of mechanical stress and strain on musculoskeletal tissues during growth, function and repair. In the past decade the gut microbiome has emerged as a contributor to disease processes throughout the body, but only recently has been shown to influence orthopaedic biomechanics. Here I review emergent findings showing that the gut microbiome can regulate important aspects of the musculoskeletal system including growth and development; tissue failure and disease; and orthopaedic surgery. These early findings suggest that the microbiome may help answer questions in orthopaedic biomechanics that are not well addressed by current interventions, and highlights the promise of the emerging field of "Musculoskeletal Microbiology".

Indexed as

ArthroplastyBiomechanicsMicrobiomeOsteoarthritisOsteoporosis

Identifiers

PMID34151053
PMCPMC8211101
OpenAlexW3157637180

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.