Evidence map›Paper›PMID 34150959›Full record

ArticleNeurobiology of stress2021

Reducing glutamic acid decarboxylase in the dorsal dentate gyrus attenuates juvenile stress induced emotional and cognitive deficits.

Kuldeep Tripathi, Yunus Emre Demiray, Stefanie Kliche, Liang Jing, Somoday Hazra, Joyeeta Dutta Hazra, Gal Richter-Levin, Oliver Stork

Open access · goldAbstract read
In one paragraph

Article in Neurobiology of stress, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

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  8. Significance of GABAInternational journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Kuldeep TripathiSagol Department of Neurobiology, University of Haifa, Israel.
Yunus Emre DemirayDepartment of Genetics & Molecular Neurobiology, Institute of Biology, Otto-von-Guericke-University, Magdeburg, Germany.
Stefanie KlicheInstitute for Molecular and Clinical Immunology, Otto-von-Guericke-University, Magdeburg, Germany.
Liang JingSagol Department of Neurobiology, University of Haifa, Israel.
Somoday HazraSagol Department of Neurobiology, University of Haifa, Israel.
Joyeeta Dutta HazraSagol Department of Neurobiology, University of Haifa, Israel.
Gal Richter-LevinSagol Department of Neurobiology, University of Haifa, Israel.
Oliver StorkDepartment of Genetics & Molecular Neurobiology, Institute of Biology, Otto-von-Guericke-University, Magdeburg, Germany.
University of Haifa · ILOtto-von-Guericke-Universität Magdeburg · DECenter for Behavioral Brain Sciences · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A high degree of regional, temporal and molecular specificity is evident in the regulation of GABAergic signaling in stress-responsive circuitry, hampering the use of systemic GABAergic modulators for the treatment of stress-related psychopathology. Here we investigated the effectiveness of local intervention with the GABA synthetic enzymes GAD65 and GAD67 in the dorsal dentate gyrus (dDG)

Indexed as

Dentate gyrusGABAGAD65GAD67PTSDStress resilience

Identifiers

PMID34150959
PMCPMC8193143
OpenAlexW3173006998

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.