ArticleOpen forum infectious diseases2019
Rapid, Sample-to-Answer Host Gene Expression Test to Diagnose Viral Infection.
Article in Open forum infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00258869 (Plasma Protein Biomarker Based Diagnostics of Outcome in Sepsis & CAP), which is not on this map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Plasma Protein Biomarker Based Diagnostics of Outcome in Sepsis & CAP
Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Molecular dynamics of the host response to Streptococcus pneumoniae pneumonia in baboons.Animal models and experimental medicine · 2025Article
- A Rapid Host Response Blood Test for Bacterial/Viral Infection Discrimination Using a Portable Molecular Diagnostic Platform.Open forum infectious diseases · 2025Article
- Predictive signature of murine and human host response to typical and atypical pneumonia.BMJ open respiratory research · 2024Article
- Host-response transcriptional biomarkers accurately discriminate bacterial and viral infections of global relevance.Scientific reports · 2023Article
- Priorities and Progress in Diagnostic Research by the Antibacterial Resistance Leadership Group.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Review
- Prospective Validation of a Rapid Host Gene Expression Test to Discriminate Bacterial From Viral Respiratory Infection.JAMA network open · 2022Article
- The host transcriptional response to Candidemia is dominated by neutrophil activation and heme biosynthesis and supports novel diagnostic approaches.Genome medicine · 2021Article
- A transcriptional signature accurately identifies Aspergillus Infection across healthy and immunosuppressed states.Translational research : the journal of laboratory and clinical medicine · 2020Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveDistinguishing bacterial, viral, or other etiologies of acute illness is diagnostically challenging with significant implications for appropriate antimicrobial use. Host gene expression offers a promising approach, although no clinically useful test has been developed yet to accomplish this. Here, Qvella's FAST HR (Richmond Hill, Ontario, Canada) process was developed to quantify previously identified host gene expression signatures in whole blood in <45 minutes.
methodWhole blood was collected from 128 human subjects (mean age 47, range 18-88) with clinically adjudicated, microbiologically confirmed viral infection, bacterial infection, noninfectious illness, or healthy controls. Stabilized mRNA was released from cleaned and stabilized RNA-surfactant complexes using e-lysis, an electrical process providing a quantitative real-time reverse transcription polymerase chain reaction-ready sample. Threshold cycle values (C
resultsReproducibility of mRNA quantification was within 1 cycle as compared to the difference seen between subjects with viral versus nonviral infection (up to 5.0 normalized C
conclusionsThese results demonstrate the ability to translate host gene expression signatures to clinical platforms for use in patients with suspected infection. CLINICAL TRIALS REGISTRATION: NCT00258869.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.