Evidence map›Paper›PMID 34150901›Full record

ReviewFrontiers in veterinary science2021

Use of Precision-Cut Tissue Slices as a Translational Model to Study Host-Pathogen Interaction.

Dominika Majorova, Elizabeth Atkins, Henny Martineau, Ivan Vokral, Dorenda Oosterhuis, Peter Olinga, Brendan Wren, Jon Cuccui, Dirk Werling

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in veterinary science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
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  3. Efficient replication of influenza D virus in the human airway underscores zoonotic potential.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  16. Mouse Models for Human Herpesviruses.Pathogens (Basel, Switzerland) · 2023
    Review
  17. Review
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Dominika MajorovaDepartment of Pathobiology and Population Sciences, Royal Veterinary College, University of London, London, United Kingdom.
Elizabeth AtkinsLondon School of Hygiene and Tropical Medicine, University of London, London, United Kingdom.
Henny MartineauDepartment of Pathobiology and Population Sciences, Royal Veterinary College, University of London, London, United Kingdom.
Ivan VokralDepartment of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University, Prague, Czechia.
Dorenda OosterhuisDepartment of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, Netherlands.
Peter OlingaDepartment of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, Netherlands.
Brendan WrenLondon School of Hygiene and Tropical Medicine, University of London, London, United Kingdom.
Jon CuccuiLondon School of Hygiene and Tropical Medicine, University of London, London, United Kingdom.
Dirk WerlingDepartment of Pathobiology and Population Sciences, Royal Veterinary College, University of London, London, United Kingdom.
Royal Veterinary College · GBUniversity of Groningen · NLUniversity of London · GBCharles University · CZLondon School of Hygiene & Tropical Medicine · GB

Funding

Biotechnology and Biological Sciences Research Council BB/G019177/1
6 · The paper itself

Abstract

The recent increase in new technologies to analyze host-pathogen interaction has fostered a race to develop new methodologies to assess these not only on the cellular level, but also on the tissue level. Due to mouse-other mammal differences, there is a desperate need to develop relevant tissue models that can more closely recapitulate the host tissue during disease and repair. Whereas organoids and organs-on-a-chip technologies have their benefits, they still cannot provide the cellular and structural complexity of the host tissue. Here, precision cut tissue slices (PCTS) may provide invaluable models for complex

Indexed as

host-pathogen interactionimmunology and infectious diseasesprecision cut tissue slicesvaccinologyveterinary

Identifiers

PMID34150901
PMCPMC8212980
OpenAlexW3166166357

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.