ReviewFrontiers in medicine2021
Urate Crystals; Beyond Joints.
Review in Frontiers in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Impact of alcohol consumption on hyperuricemia and gout: a systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- Development and validation of a risk models for gout in patients with diabetic kidney disease.BMC endocrine disorders · 2026Article
- Pro-Inflammatory Synergy Between IL-17, IL-1 and Hyperuricemia in Psoriatic Arthritis: Clinical Implications of a Pilot Study.Diseases (Basel, Switzerland) · 2026Article
- Dose-Sparing Efficacy of d-Limonene with Low-Dose Allopurinol in a Dual Model of Hyperuricemia and Gouty Arthritis in Rats.Nutrients · 2025Article
- Association between coronary monosodium urate deposits at DECT and high-risk coronary plaque phenotypes and other features in gout patients.European radiology experimental · 2025Article
- Paravertebral crystal deposition disease: a retrospective study of clinical presentation, prevalence, and CT imaging findings.Skeletal radiology · 2025Article
- Major cardiovascular events in patients with cardiovascular monosodium urate deposits in atherosclerotic plaques.Rheumatology (Oxford, England) · 2025Article
- The pathogenesis of gout.Journal of rheumatic diseases · 2025Review
- Article
- Artificial Intelligence-Assisted Stimulated Raman Histology: New Frontiers in Vibrational Tissue Imaging.Cancers · 2024Review
- Association between serum uric acid and kidney disease with pediatric focus.Childhood kidney diseases · 2024Review
- Review: The Role of Dual-Energy Computed Tomography in Detecting Monosodium Urate Deposits in Vascular Tissues.Current rheumatology reports · 2024Review
- Article
- Establishment of Polydopamine-Modified HK-2 Cell Membrane Chromatography and Screening of Active Components fromInternational journal of molecular sciences · 2024Article
- Dual-energy CT: Impact of detecting bone marrow oedema in occult trauma in the Emergency.BJR open · 2024Review
- [Unusual case of pseudotumoral hip injury due to gout: case report].Revista medica del Instituto Mexicano del Seguro Social · 2023Article
- Antiphagocytic Properties of Polygallic Acid with Implications in Gouty Inflammation.Inflammation · 2023Article
- Increased prevalence of periodontitis with hypouricemic status: findings from the Korean National Health and Nutrition Examination Survey, 2016-2018.Journal of periodontal & implant science · 2023Article
- Spinal gout diagnosis in chiropractic practice: narrative review.The Journal of the Canadian Chiropractic Association · 2023Article
- A Role of Sodium-Glucose Co-Transporter 2 in Cardiorenal Anemia Iron Deficiency Syndrome.International journal of molecular sciences · 2023Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gout is the most common inflammatory arthropathy caused by the deposition of monosodium urate (MSU) crystals. The burden of gout is substantial with increasing prevalence of gout globally. The prevalence of Gout in the United States has increased by over 7% in the last two decades. Initially, it was believed that MSU crystal deposits occur only in the joints with the involvement of the periarticular soft tissues, but recent studies have shown the presence of MSU crystal deposition in extra-articular sites as well. Human plasma becomes supersaturated with uric acid at 6.8 mg/dl, a state called hyperuricemia. Beyond this level, uric acid crystals precipitate out of the plasma and deposit in soft tissues, joints, kidneys, etc. If left untreated, hyperuricemia leads to chronic gout characterized by the deposition of tophi in soft tissues such as the joints, tendons, and bursae. With the advent of newer imaging techniques such as DECT, MSU crystals can be visualized in various extra-articular sites. Extra-articular deposition of MSU crystals is believed to be the causative factor for the development of multiple comorbidities in gout patients. Here, we review the literature on extra-articular deposition of urate crystals and the role of dual-energy computed tomography (DECT) in elucidating multi-organ involvement. DECT has emerged as an invaluable alternative for accurate and efficient MSU crystal deposition detection. Future studies using DECT can help determine the clinical consequences of extra-articular deposition of MSU in gout patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.