ArticleFrontiers in cell and developmental biology2021
RNA Network Interactions During Differentiation of Human Trophoblasts.
Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 10 citations in OpenAlex.
- The impact of opioids on the transcriptional landscape of human villous trophoblasts.Placenta · 2023Article
- Defining trophoblast injury patterns in the transcriptomes of dysfunctional placentas.Placenta · 2023Article
- Integrated unbiased multiomics defines disease-independent placental clusters in common obstetrical syndromes.BMC medicine · 2023Article
- Ex Vivo Infection of Human Placental Explants byPathogens (Basel, Switzerland) · 2022Article
- Expression profiling of lncRNAs and mRNAs in placental site trophoblastic tumor (PSTT) by microarray.International journal of medical sciences · 2022Article
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6 authors at 2 institutions in 1 country.
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Abstract
In the human placenta, two trophoblast cell layers separate the maternal blood from the villous basement membrane and fetal capillary endothelial cells. The inner layer, which is complete early in pregnancy and later becomes discontinuous, comprises the proliferative mononuclear cytotrophoblasts, which fuse together and differentiate to form the outer layer of multinucleated syncytiotrophoblasts. Because the syncytiotrophoblasts are responsible for key maternal-fetal exchange functions, tight regulation of this differentiation process is critical for the proper development and the functional role of the placenta. The molecular mechanisms regulating the fusion and differentiation of trophoblasts during human pregnancy remain poorly understood. To decipher the interactions of non-coding RNAs (ncRNAs) in this process, we exposed cultured primary human trophoblasts to standard
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