Evidence map›Paper›PMID 34150675›Full record

ArticleFrontiers in cellular and infection microbiology2021

Development of a Fluorescent Assay to Search New Drugs Using Stable tdTomato-

María Fernanda García-Bustos, Agustín Moya Álvarez, Cecilia Pérez Brandan, Cecilia Parodi, Andrea Mabel Sosa, Valeria Carolina Buttazzoni Zuñiga, Oscar Marcelo Pastrana, Paula Manghera, Pablo Alejandro Peñalva, Jorge Diego Marco and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Challenges and Tools for In VitroPathogens (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

María Fernanda García-BustosEscuela Universitaria en Ciencias de la Salud y Facultad de Ciencias Agrarias y Veterinarias, Universidad Católica de Salta, Salta, Argentina.
Agustín Moya ÁlvarezInstituto de Patología Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) - Universidad Nacional de Salta, Salta, Argentina.
Cecilia Pérez BrandanInstituto de Patología Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) - Universidad Nacional de Salta, Salta, Argentina.
Cecilia ParodiInstituto de Patología Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) - Universidad Nacional de Salta, Salta, Argentina.
Andrea Mabel SosaInstituto de Patología Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) - Universidad Nacional de Salta, Salta, Argentina.
Valeria Carolina Buttazzoni ZuñigaEscuela Universitaria en Ciencias de la Salud y Facultad de Ciencias Agrarias y Veterinarias, Universidad Católica de Salta, Salta, Argentina.
Oscar Marcelo PastranaEscuela Universitaria en Ciencias de la Salud y Facultad de Ciencias Agrarias y Veterinarias, Universidad Católica de Salta, Salta, Argentina.
Paula MangheraEscuela Universitaria en Ciencias de la Salud y Facultad de Ciencias Agrarias y Veterinarias, Universidad Católica de Salta, Salta, Argentina.
Pablo Alejandro PeñalvaEscuela Universitaria en Ciencias de la Salud y Facultad de Ciencias Agrarias y Veterinarias, Universidad Católica de Salta, Salta, Argentina.
Jorge Diego MarcoInstituto de Patología Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) - Universidad Nacional de Salta, Salta, Argentina.
Paola Andrea BarrosoInstituto de Patología Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) - Universidad Nacional de Salta, Salta, Argentina.
National University of Salta · ARUniversidad Católica de Salta · ARConsejo Nacional de Investigaciones Científicas y Técnicas · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimonials continue to be considered the first-line treatment for leishmaniases, but its use entails a wide range of side effects and serious reactions. The search of new drugs requires the development of methods more sensitive and faster than the conventional ones. We developed and validated a fluorescence assay based in the expression of tdTomato protein by

Indexed as

Antiprotozoal AgentsLeishmaniaPharmaceutical PreparationsAnimalsFlavonoidsLuminescent ProteinsMiceMice, Inbred BALB CRed Fluorescent ProteinAntiprotozoal AgentsFlavonoidsgalanginLuminescent ProteinsPharmaceutical PreparationsRed Fluorescent ProteinflavonoidsfluorescencegalanginL. (L.) amazonensistdTomato

Identifiers

PMID34150675
PMCPMC8213385
OpenAlexW3167135641

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.