Evaluation of the effect of ultrasound interventional injection of cisplatin in the treatment of liver cancer.

objectiveTo evaluate the effect of ultrasound interventional injection of cisplatin in the treatment of hepatocellular carcinoma (HCC).

methods68 patients with HCC admitted to our hospital from February 2016 to February 2018 were enrolled. According to the different treatment methods, they were divided into a study group and a control group. The control group was treated with hepatic artery embolization chemotherapy (n=34), the study group adopted interventional ultrasound injection of cisplatin (n=34). The clinical treatment effects of the two groups of patients were compared; the liver function and the occurrence of adverse reactions were compared; all patients were followed up for 24 months, and their progressive-free survival (PFS) was also compared.

resultsThe study group had higher total effective rate compared with the control group (91.18% vs 67.65%) (P<0.05); the AST, ALT, T-BIL and D-BIL levels of the two groups decreased remarkably after treatment, and the reduction in the study group was more obvious (P<0.05); the levels of VEGF, AFP and CEA of the two groups reduced noticeably after treatment, and the decrease in the study group was more significant (P<0.05); the total incidence of adverse reactions in the study group and the control group was 2.94% and 23.53% respectively, (P<0.05); the two groups were followed up for 24 months, and the disease control rate (DCR) of the control group was 58.82%, significantly lower than 85.29% in the study group; the PFS time of the control group was (15.68±4.23) lower than that of the study group (18.12±5.42) (P<0.05).

conclusionInterventional ultrasound injection of cisplatin in the treatment of HCC has a definite effect. It can effectively relieve liver damage, reduce adverse reactions, improve serum tumor marker levels, and boost the DCR and PFS time of tumor patients.