ArticleAmerican journal of translational research2021
Effect of left or right gastric artery interventional embolization on obesity and ghrelin/leptin expression in pigs.
Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 citations in OpenAlex.
- Weight Loss and Gastrointestinal Hormone Variation Caused by Gastric Artery Embolization: An Updated Analysis Study.Frontiers in endocrinology · 2022Review
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
objectiveTo investigate the effect of left or right gastric artery interventional embolization on obesity and ghrelin/leptin expression in pigs.
methodsThirty-two female Wuzhishan pigs aged 3-4 months were randomly divided into four groups, with eight pigs in each group: obesity + left gastric artery embolization group, obesity + right gastric artery embolization group, obesity + sham surgery group and healthy control group. The body weight and serum levels of ghrelin, leptin, interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) before the operation, one month and three months after the operation, and the gastric pathology three months after the operation were compared.
resultsThe preoperative body weight, ghrelin level, leptin level, IL-6 level and TNF-α level of the obesity + sham surgery group, obesity + left gastric artery embolization group and obesity + right gastric artery embolization group were higher than those of the healthy control group (all P<0.05). One month after the operation, the body weight, ghrelin level, leptin level, IL-6 level and TNF-α level of the obesity + sham surgery group, obesity + left gastric artery embolization group and obesity + right gastric artery embolization group were higher than those of the healthy control group. The body weight, ghrelin level, IL-6 level and TNF-α level of the obesity + sham surgery group were higher than those of the obesity + left artery embolization group and obesity + right gastric artery embolization group (all P<0.05). Three months after the operation, the body weight, ghrelin level, leptin level, IL-6 level and TNF-α level of the obesity + sham surgery group were higher than those of the obesity + left artery embolization group, obesity + right artery embolization group and the healthy control group (all P<0.05).
conclusionLeft or right gastric artery interventional embolization in pigs can effectively reduce body weight, which may be related to the reduced secretion of ghrelin, leptin and inflammatory factors. However, the clinical application and safety of left or right gastric artery embolization still need further study.
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34150142PMC8205808W3173995408What OpenQuestion holds
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