Evidence map›Paper›PMID 34150138›Full record

ArticleAmerican journal of translational research2021

LNG-IUS combined with progesterone ameliorates endometrial thickness and pregnancy outcomes of patients with early-stage endometrial cancer or atypical hyperplasia.

Fang Fang, Hao Xu, Ling Wu, Linyi Hu, Ying Liu, Yinnan Li, Chunhua Zhang

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.

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  16. Contraception During Perimenopause: Practical Guidance.International journal of women's health · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Fang FangDepartment of Gynaecology, Huaian Maternal and Child Health Hospital Huaian 223001, Jiangsu Province, China.
Hao XuDepartment of Gynaecology, Aikang Hospital Gynecolgy Huangshi 435000, Huangshi, Hubei Province, China.
Ling WuDepartment of Gynaecology, Huaian Maternal and Child Health Hospital Huaian 223001, Jiangsu Province, China.
Linyi HuDepartment of Gynaecology, Huaian Maternal and Child Health Hospital Huaian 223001, Jiangsu Province, China.
Ying LiuDepartment of Gynaecology, Huaian Maternal and Child Health Hospital Huaian 223001, Jiangsu Province, China.
Yinnan LiDepartment of Gynaecology, Huaian Maternal and Child Health Hospital Huaian 223001, Jiangsu Province, China.
Chunhua ZhangDepartment of Gynaecology, Huaian Maternal and Child Health Hospital Huaian 223001, Jiangsu Province, China.
Huaian First People’s Hospital · CNHuangshi Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine the positive effect of levonorgestrel-releasing intrauterine system (LNG-IUS) combined with progesterone on endometrial thickness and pregnancy outcomes of patients with atypical endometrial hyperplasia (AEH) or early-stage endometrial cancer (EEC).

methodsPatients with AEH or EEC admitted to our hospital were enrolled, and assigned to a control group (con group) and a combination group (com group). Patients in the con group were treated with LNG-IUS, while those in the com group were treated with LNG-IUS combined with progesterone. After treatment, the two groups were compared in efficacy, menstrual blood volume (pictorial blood loss assessment chart (PBAC) score), and changes in endometrial thickness. In addition, the incidence of adverse drug reactions and pregnancy outcomes of the patients were analyzed.

resultsBefore treatment, there was no significant difference in PBAC score and endometrial thickness between patients with AEH or EEC in the con group and those in the com group, but after 3 months and 6 months of treatment, the com group got a better PBAC score and better changes of endometrial thickness than the con group, and the incidence of adverse drug reactions in the com group was also significantly lower than that in the con group. In addition, the follow-up results of pregnancy outcomes of patients showed that the fertility rate and total effective rate of the com group were both significantly higher than those of the con group (both

conclusionLNG-IUS combined with progesterone is more effective in treating patients with AEH or EEC. It can effectively improve the endometrial thickness of patients and fertility rate of those with fertility requirements after treatment.

Indexed as

atypical endometrial hyperplasiaearly-stage endometrial cancerendometrial thicknessLevonorgestrel-releasing intrauterine systempregnancy outcomeprogesterone

Identifiers

PMID34150138
PMCPMC8205653
OpenAlexW3177056262

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.