Effect of left gastric artery embolization on obesity and ghrelin/leptin levels in pigs.

Hui Liu, Xiangying Li, Rihui Chen, Dingcheng Liu, Chao Tong

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Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors at 1 institution in 1 country.

Hui LiuDepartment of Interventional Radiology, Central South University, Xiangya School of Medicine Affiliated Haikou Hospital Haikou, Hainan Province, China.

Xiangying LiDepartment of Radiology, Central South University, Xiangya School of Medicine Affiliated Haikou Hospital Haikou, Hainan Province, China.

Rihui ChenDepartment of Interventional Radiology, Central South University, Xiangya School of Medicine Affiliated Haikou Hospital Haikou, Hainan Province, China.

Dingcheng LiuDepartment of Interventional Radiology, Central South University, Xiangya School of Medicine Affiliated Haikou Hospital Haikou, Hainan Province, China.

Chao TongDepartment of Interventional Radiology, Central South University, Xiangya School of Medicine Affiliated Haikou Hospital Haikou, Hainan Province, China.

Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the influence of left gastric artery embolization (LGAE) on obesity and Ghrelin/Leptin levels in pigs.

methodsHealthy female Wuzhishan piglets aged 3-4 months were allocated into obesity + LGAE group, obesity group, control group (fed with a normal diet; n=8 for each group). Body weight, serum Ghrelin, Leptin, glucose and insulin levels were compared before surgery, 1 month and 3 months after surgery.

resultsPiglets in obesity group and obesity + LGAE group were heavier than those in control group before and 1 month after surgery (P<0.001), and in obesity group were heavier than those in obesity + LGAE group 1 month after surgery (P<0.05). A significant decrease in body weight was observed in obesity + LGAE group 3 months after surgery (P<0.05), and the obesity group showed heavier weight than the other two groups (P<0.001). Ghrelin levels in obesity group and obesity + LGAE group were higher than those in control group before and 1 month after surgery (P<0.001), and in obesity group were higher than those in obesity + LGAE group 1 month after surgery (P<0.05). They showed an evident decrease in obesity + LGAE group 3 months after surgery (P<0.05), and in obesity group were higher than that in the other two groups (P<0.01). Leptin levels in obesity group and obesity + LGAE group were higher than those in control group before surgery (P<0.01) and 1 month after surgery (P<0.05). They decreased significantly in obesity + LGAE group 3 months after surgery (P<0.01), and in obesity group were higher than those in the other two groups (P<0.01).

conclusionLGAE greatly contributes to weight loss possibly by reducing the secretion of Ghrelin and Leptin.

Indexed as

Ghrelin/LeptininterventionLeft gastric artery embolizationobesitywuzhishan piglet

Identifiers

PMID34150132

PMCPMC8205667

OpenAlexW3176605384

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.