Evidence map›Paper›PMID 34150128›Full record

ArticleAmerican journal of translational research2021

Expression level of miRNA in the peripheral blood of patients with multiple myeloma and its clinical significance.

Guangbao Li, Jianwen Yin, Zutong Wu, Shizhong Li, Aijun He, Zhenzhen Sun

Open access · greenAbstract read
PubMed Full text at PMC
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Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Guangbao LiDepartment of Orthopedics, The First Affiliated Hospital of Shaoyang University Shaoyang 422000, P. R. China.
Jianwen YinDepartment of Orthopedics, The First Affiliated Hospital of Shaoyang University Shaoyang 422000, P. R. China.
Zutong WuDepartment of Orthopedics, The First Affiliated Hospital of Shaoyang University Shaoyang 422000, P. R. China.
Shizhong LiDepartment of Orthopedics, The First Affiliated Hospital of Shaoyang University Shaoyang 422000, P. R. China.
Aijun HeDepartment of Orthopedics, The First Affiliated Hospital of Shaoyang University Shaoyang 422000, P. R. China.
Zhenzhen SunDepartment of Peadiatrics, The First Affiliated Hospital of Shaoyang University Shaoyang 422000, P. R. China.
The Central Hospital of Shaoyang · CNShaoyang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the expression level of serum miRNA-192-5p and its clinical value in the diagnosis and care of patients with multiple myeloma (MM).

methodsEighty-eight patients with MM admitted to our hospital from June 2017 to April 2020 were selected as the observation group. In addition, 70 patients who received osteoporosis testing in our hospital in the corresponding period but were excluded from having MM and haematological malignancy were selected as the control group. The relative expression level of serum miRNA-192-5p was detected. The expression level of serum miRNA and its correlation with patient-related clinical parameters were compared and analyzed. The ROC curve was used to analyze its diagnostic efficacy for MM.

resultsThe relative expression level of serum miRNA-192-5p in MM patients was remarkably lower than that in the control group (P < 0.05); the AUC area of serum miRNA-192-5p in patients with a diagnosis of MM was 0.853, with a cutoff value of 0.72, the sensitivity of 86.30%, and the specificity of 81.20%, P = 0.030. The relative expression level of miRNA-192-5p in the serum of patients with high β2-MG and creatinine levels was markedly reduced compared to that in patients with low β2-MG levels (P < 0.05); the relative expression level of miRNA-192-5p in the serum of patients with low hemoglobin and albumin levels was markedly reduced compared to that in patients with normal hemoglobin and albumin (P < 0.05); and there was significantly negative correlation between the relative expression level of miRNA-192-5p in the serum of MM patients and IgG and IgA levels, respectively (P < 0.05).

conclusionmiRNA-192-5p may serve as an auxiliary diagnostic tool in the diagnosis of MM. Furthermore, because there is certain correlation between serum miRNA-192-5p and MM progression and prognosis, it may be regarded as a novel marker for MM monitoring.

Indexed as

diagnosismiRNA-192-5pMultiple myeloma

Identifiers

PMID34150128
PMCPMC8205780
OpenAlexW3174977888

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