Evidence map›Paper›PMID 34150054›Full record

ArticleAmerican journal of translational research2021

Low expression of developing brain homeobox 2 (Dbx2) may serve as a biomarker to predict poor prognosis in endometrial cancer.

Xinlu Zhang, Yaping Wang, Shujun Zhao, Qiaohong Qin, Min Zhang, Yi Jiang, Hai Zhu, Hongyu Li

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Xinlu ZhangGynecologic Oncology, The Third Affiliated Hospital of Zhengzhou University Zhengzhou 450000, Henan, P. R. China.
Yaping WangGynecologic Oncology, The Third Affiliated Hospital of Zhengzhou University Zhengzhou 450000, Henan, P. R. China.
Shujun ZhaoGynecologic Oncology, The Third Affiliated Hospital of Zhengzhou University Zhengzhou 450000, Henan, P. R. China.
Qiaohong QinGynecologic Oncology, The Third Affiliated Hospital of Zhengzhou University Zhengzhou 450000, Henan, P. R. China.
Min ZhangGynecologic Oncology, The Third Affiliated Hospital of Zhengzhou University Zhengzhou 450000, Henan, P. R. China.
Yi JiangGynecologic Oncology, The Third Affiliated Hospital of Zhengzhou University Zhengzhou 450000, Henan, P. R. China.
Hai ZhuGynecologic Oncology, The Third Affiliated Hospital of Zhengzhou University Zhengzhou 450000, Henan, P. R. China.
Hongyu LiGynecologic Oncology, The Third Affiliated Hospital of Zhengzhou University Zhengzhou 450000, Henan, P. R. China.
Third Affiliated Hospital of Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveFor investigating Dbx2's expression in endometrial cancer (EC) and its effect on prognosis of patients with EC.

methodsA comparison was performed in the Cancer Genome Atlas (TCGA) database in terms of the expression profiling of EC and the survival data. To obtain differential expression genes (DEGs), Volcano plot and Venn analysis were adopted. DEGs function was performed by carrying out the GO annotation analysis (GO) and gene set enrichment analysis (GSEA). In clinical EC samples, PCR was applied to the verification of Dbx2's expression.

resultsDbx2 was a downregulated expression in tumor tissues. Dbx2 can have a poor prognosis role in EC by regulating the apoptotic signaling pathway and the immune pathway. Lower expression of Dbx2 was related to lymph node metastasis and FIGO stage.

conclusionDbx2 is downregulated in endometrial cancer, which serves as a biomarker to predict poor prognosis.

Indexed as

bioinformatics analysisbiomarkerDbx2Endometrial cancerprognosis

Identifiers

PMID34150054
PMCPMC8205784
OpenAlexW3176240915

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.