ArticleAmerican journal of translational research2021
Plasma cytokine changes and its clinical significance in intracranial infection secondary to traumatic brain injury.
Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
- Association of the prealbumin-albumin nutritional index with short-term mortality in hospitalized patients with traumatic brain injury.Frontiers in nutrition · 2026Article
- Changes in serum concentration of perioperative inflammatory cytokines following the timing of surgery among mild-moderate traumatic brain injury patients and factors associated.Frontiers in neurology · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to investigate the plasma cytokine changes and its clinical significance in intracranial infection secondary to traumatic brain injury.
methodsA total of 60 cases with intracranial infection secondary to traumatic brain injury admitted to our hospital from January 2017 to December 2019 were selected as the research objects, of whom, 24 cases with mild infection, 20 with moderate infection, and 16 with severe infection. Another 60 cases without intracranial infection secondary to traumatic brain injury during the same period were selected as the uninfected group. A comparison of infected and uninfected groups on changes of plasma cytokines (IL-1β, IL-2, IL-6, IL-8, TNF-α, IFN-γ) and high mobility group-1 protein (HMGB1) were conducted to analyze the correlation between plasma cytokines and disease severity.
resultsThe data of IL-1β, IL-2, IL-6, IL-8, TNF-α, IFN-γ and HMGB1 levels in both groups on day 1, day 3 and day 5 after the surgery were obtained. The results indicated that for infected group, the differences were significant among these 3 days (P<0.05), and the data on day 5 were all higher than that on day 1 and day 3 (P<0.05). While for uninfected group, there was no significant difference among those 3 days (P>0.05). The differences in different severity of infection on day 5 showed statistically significance (P<0.05), and it was positively correlated with the severity (P<0.05).
conclusionThe cytokines content in intracranial infection secondary to traumatic brain injury increased significantly, which was closely related to the severity of the infection. These factors can be used as monitoring indicators for diagnosis of intracranial infection and assessment ofthe severity.
Indexed as
Identifiers
34150037PMC8205820W3175269537What OpenQuestion holds
Registered trials
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