ArticleAmerican journal of translational research2021
Placenta inflammation is closely associated with gestational diabetes mellitus.
Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers, 3 of them syntheses that pooled it.
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Who cites it
112 citing papers in PubMed, 3 syntheses or guidelines pooled it, 122 citations in OpenAlex.
- Decoding the molecular landscape of the placenta in maternal diabetes: a systematic review of high-throughput data.Journal of molecular endocrinology · 2026Pooled it
- Effect of maternal vitamin D status on risk of adverse birth outcomes: a systematic review and dose-response meta-analysis of observational studies.European journal of nutrition · 2022Pooled it
- Chemokines in Gestational Diabetes Mellitus.Frontiers in immunology · 2022Pooled it
- Exploration of the Potential Mechanisms of Yinqiao Powder in Treating Atopic Dermatitis: Integrating Network Pharmacology, Single-Cell, and Bulk RNA Sequencing.Journal of asthma and allergy · 2026Trial
- Identification and validation of palmitoylation-associated biomarkers in major depressive disorder.Scientific reports · 2026Article
- Microbial Signatures in Head and Neck versus Gastrointestinal Tumors: Identification and Prognostic Modeling.Polish journal of microbiology · 2026Article
- The Risk Factors for Placental Abruption in Preeclamptic Pregnancies: A Retrospective Case-Control Study.The journal of obstetrics and gynaecology research · 2026Article
- Identification of Prognostic Values of Neutrophil Extracellular Traps-Related Genes in Glioma Based on Bioinformatics.Immunity, inflammation and disease · 2026Article
- Identification and validation of prognostic genes associated with M2 macrophage and heme metabolism in lung adenocarcinoma through bulk and single-cell RNA sequencing analysis.Discover oncology · 2026Article
- Abnormal Galectin Signaling in the Pathomechanisms of Placental Dysfunction in Gestational Diabetes Mellitus.International journal of molecular sciences · 2026Review
- Application of XGBoost and logistic regression in predicting 90 days mortality for elderly severe acute renal failure patients.Scientific reports · 2026Article
- BAX as a Biomarker for Predicting Immunotherapeutic Efficacy in Uveal Melanoma Patients: A Comprehensive Analysis.Molecular biotechnology · 2026Article
- Effects of nucleic acid metabolism on prognosis and immune invasion of triple-negative breast cancer.Genes and immunity · 2026Article
- Genetic insights and mechanistic parallels in gestational diabetes mellitus and type 2 diabetes.Nature communications · 2026Article
- Mitochondrial-related biomarkers as the diagnostic markers in sepsis induced acute respiratory distress syndrome.European journal of medical research · 2026Article
- Analysis of immune and autophagy-related genes and their regulatory mechanisms in osteoporosis patients post-menopause.Frontiers in endocrinology · 2026Article
- Immune dysregulation linking pre-pregnancy obesity to gestational diabetes mellitus.Frontiers in immunology · 2026Review
- Secreted frizzled-related protein 3 is associated with metabolic disturbances in gestational diabetes.Frontiers in endocrinology · 2026Article
- Identification and validation of biomarkers associated with lactic acid metabolism in diabetic nephropathy.PeerJ · 2026Article
- Decoding NETosis-associated immune dysregulation in diffuse large B-cell lymphoma through integrative multi-omics and machine learning.Frontiers in cell and developmental biology · 2026Article
52 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the potential role of placenta inflammation in gestational diabetes mellitus (GDM) and construct a model for the diagnosis of GDM.
methodsIn this study, transcriptome-wide profiling datasets, GSE70493 and GSE128381 were downloaded from Gene Expression Omnibus (GEO) database. Significant immune-related genes were identified separately to be the biomarkers for the diagnosis of GDM by using random forest model (RF), support vector machine model (SVM), and generalized linear model (GLM).
resultsRF was the best model and was used to select the four key immune-related genes (FABP4, DKK1, CXCL10, and IL1RL1) to diagnose GDM. A nomogram model was constructed to predict GDM based on the four key immune-related genes by using "rms" package. The relative proportion of 22 immune cell types were calculated by using CIBERSORT algorithm. Higher M1 macrophage ratio and lower M2 macrophage ratio in GDM placenta compared to normal patients were observed.
conclusionsThis study provides clues that inflammation was correlated with GDM and suggests inflammation may be the cause and also the potential targets of GDM.
Indexed as
Identifiers
34149999PMC8205654W3174286082What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.