Evidence map›Paper›PMID 34149867›Full record

ArticleMental health and physical activity2021

Aerobic exercise reduces anxiety and fear ratings to threat and increases circulating endocannabinoids in women with and without PTSD.

Kevin M Crombie, Josh M Cisler, Cecilia J Hillard, Kelli F Koltyn

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Mental health and physical activity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06213883 (Characterizing Acute Exercise Response in Restrictive Eating Disorders), which is not on this map. Cited by 19 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 4 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06213883 nacompletednot on this mapstarted 2023, after this paper: background citation

Characterizing Acute Exercise Response in Restrictive Eating Disorders

TypeinterventionalSponsorUniversity of Wisconsin, MadisonRan2023 to 2025Enrolled74ConditionsEating DisordersArmsBiobehavioral Response to in-lab exposure to physical activity
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Do Endocannabinoids Cause the Runner's High? Evidence and Open Questions.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2023
    Pooled it
  4. Pooled it
  5. Article
  6. Review
  7. Understanding the Role of Endocannabinoids in Posttraumatic Stress Disorder.International journal of molecular sciences · 2025
    Review
  8. Review
  9. Review
  10. Article
  11. Exercise and PTSD.Current topics in behavioral neurosciences · 2024
    Review
  12. Exercise and Anxiety.Current topics in behavioral neurosciences · 2024
    Review
  13. Exercise and Acute Affect.Current topics in behavioral neurosciences · 2024
    Article
  14. Article
  15. The Endocannabinoid System and Physical Exercise.International journal of molecular sciences · 2023
    Review
  16. Article
  17. Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kevin M CrombieDepartment of Kinesiology at the University of Wisconsin-Madison, Madison, WI - USA.
Josh M CislerDepartment of Psychiatry at the University of Wisconsin - Madison, Madison, WI - USA.
Cecilia J HillardNeuroscience Research Center and Department of Pharmacology and Toxicology at the Medical College of Wisconsin, Milwaukee, WI - USA.
Kelli F KoltynDepartment of Kinesiology at the University of Wisconsin-Madison, Madison, WI - USA.
University of Wisconsin–Madison · USMedical College of Wisconsin · US

Funding

The influence of exercise in reducing anxiety and fear responses via the endocannabinoid system in trauma exposed adults with and without PTSDF31MH115561 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI CROMBIE, KEVIN M · 2018 to 2019
$54k
NIMH NIH HHS F31 MH115561
6 · The paper itself

Abstract

Reductions in state anxiety have been reported following an acute bout of aerobic exercise. However, less is known regarding anxiety and fear ratings to specific threatening stimuli following an acute bout of aerobic exercise in women with PTSD. Moreover, the mechanisms responsible for the anxiolytic effects of exercise are not fully understood, although recent studies suggest a role for the endocannabinoid (eCB) system. Thus, this study utilized a randomized, counterbalanced approach to examine anxiety and fear ratings to predictable or unpredictable electric shock administration and circulating concentrations of eCBs and mood states immediately following moderate-intensity aerobic exercise (30 min on treadmill at 70-75% maximum heart rate) and a quiet rest control condition in women with and without a history of trauma, and in women with PTSD (N=42). Results revealed that anxiety and fear ratings to unpredictable and predictable threats were significantly (

Identifiers

PMID34149867
PMCPMC8208522
OpenAlexW3096673036

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.