ArticleIranian journal of veterinary research2021
The effect of L-tryptophan on the food intake, rectal temperature, and blood metabolic parameters of 7-day-old chicks during feeding, fasting, and acute heat stress.
Article in Iranian journal of veterinary research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 3 citations in OpenAlex.
- Effect of rumen-protected L-tryptophan on productivity and metabolic responses in dry Holstein cows under heat stress conditions.Scientific reports · 2026Article
- Tryptophan Supplementation Reduces Schizophrenia-Like Symptoms in Apomorphine Treated Rats: Role of D2, GABA, and Glutamate Receptor Expression.International journal of tryptophan research : IJTR · 2026Article
- Tryptophan Alleviates Acute Heat Stress-Induced Impairment of Antioxidant Status and Mitochondrial Function in Broilers.Frontiers in veterinary science · 2022Article
- A review of heat stress in chickens. Part II: Insights into protein and energy utilization and feeding.Frontiers in physiology · 2022Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExposure to a high ambient temperature (HT) can cause heat stress, which has a negative impact on physiological functions. L-tryptophan (L-Trp) as a precursor of serotonergic and kynurenine (Kyn) pathways, has a calmative effect during different stress statuses.
aimsThis study was carried out to determine the influence of intraperitoneal injection of Trp on feeding behavior, rectal temperature, and some blood parameters in the heat stress condition.
methodsL-tryptophan (25 and 50 mg/kg body weight, BW) was administered intraperitoneally during either HT (39°C) or control temperature (CT; 31°C) for 5 h whilst fed or fasted in 7-day-old chicks.
resultsL-tryptophan caused elevation in decreased food intake and significantly decreased rectal temperature during acute heat stress at the dose of 50 mg/kg BW. Rectal temperature reduced in the fasted state at the dose of 50 mg/kg BW, and at the dose of 25 mg/kg BW Trp in the fed state in comparison with the other experimental groups. Reduction of serum glucose, triglyceride, and corticosterone levels was seen during the fed state. L-tryptophan had a significant reducing effect on the serum corticosterone level in the fasted state in comparison with the fed state, and also revealed a significant decline at the dose of 25 mg/kg BW on the elevated serum corticosterone under heat stress.
conclusionAdministration of L-tryptophan leads to increase cumulative food intake and decrease rectal temperature during heat stress. Also, L-Trp causes to decline increased serum corticosterone level under heat stress and fasted state. These findings indicated the potential regulator role of Trp to modulate stress response in heat-exposed chicks.
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