Evidence map›Paper›PMID 34149716›Full record

ArticleFrontiers in immunology2021

IFN-β Acts on Monocytes to Ameliorate CNS Autoimmunity by Inhibiting Proinflammatory Cross-Talk Between Monocytes and Th Cells.

Javad Rasouli, Giacomo Casella, Larissa L W Ishikawa, Rodolfo Thome, Alexandra Boehm, Adam Ertel, Carolina R Melo-Silva, Elisabeth R Mari, Patrizia Porazzi, Weifeng Zhang and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Javad RasouliDepartment of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.
Giacomo CasellaDepartment of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.
Larissa L W IshikawaDepartment of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.
Rodolfo ThomeDepartment of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.
Alexandra BoehmDepartment of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.
Adam ErtelSidney Kimmel Cancer Center, Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, United States.
Carolina R Melo-SilvaDepartment of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA, United States.
Elisabeth R MariDepartment of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.
Patrizia PorazziSidney Kimmel Cancer Center, Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, United States.
Weifeng ZhangDepartment of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.
Dan XiaoDepartment of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.
Luis J SigalDepartment of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA, United States.
Paolo FortinaSidney Kimmel Cancer Center, Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, United States.
Guang-Xian ZhangDepartment of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.
Abdolmohamad RostamiDepartment of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.
Bogoljub CiricDepartment of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.
Thomas Jefferson University · USSapienza University of Rome · ITSidney Kimmel Cancer Center · US

Funding

X-Ray Crystallography and Macromolecular CharacterizationP30CA056036 · NCI · THOMAS JEFFERSON UNIVERSITY · PI Andrew Chapman · 1995 to 2026
$94.8M
Mechanisms of GM-CSF effect in CNS autoimmune demyelinationR01AI124386 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI ROSTAMI, A.M. · 2017 to 2021
$1.9M
T and B cell derived GM-CSF in EAER21AI146796 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI CIRIC, BOGOLJUB · 2019 to 2020
$429k
NCI NIH HHS P30 CA056036NIAID NIH HHS R01 AI124386NIAID NIH HHS R21 AI146796
6 · The paper itself

Abstract

IFN-β has been the treatment for multiple sclerosis (MS) for almost three decades, but understanding the mechanisms underlying its beneficial effects remains incomplete. We have shown that MS patients have increased numbers of GM-CSF

Indexed as

AutoimmunityCell CommunicationAnimalsAntigen-Presenting CellsCytokinesDisease Models, AnimalDisease SusceptibilityEncephalomyelitis, Autoimmune, ExperimentalGranulocyte-Macrophage Colony-Stimulating FactorInterferon-betaMiceMice, KnockoutMonocytesT-Lymphocytes, Helper-InducerCytokinesGranulocyte-Macrophage Colony-Stimulating FactorInterferon-betaEAEGM-CSFIFN-βmonocytesmultiple sclerosisTh cells

Identifiers

PMID34149716
PMCPMC8213026
OpenAlexW3167060250

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.