Evidence map›Paper›PMID 34149703›Full record

ReviewFrontiers in immunology2021

Laboratory Mice - A Driving Force in Immunopathology and Immunotherapy Studies of Human Multiple Myeloma.

Michael Pisano, Yan Cheng, Fumou Sun, Binod Dhakal, Anita D'Souza, Saurabh Chhabra, Jennifer M Knight, Sridhar Rao, Fenghuang Zhan, Parameswaran Hari and 1 more

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Mouse models of human multiple myeloma subgroups.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Michael PisanoDivision of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.
Yan ChengDivision of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.
Fumou SunDivision of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.
Binod DhakalDivision of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.
Anita D'SouzaDivision of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.
Saurabh ChhabraDivision of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.
Jennifer M KnightDepartments of Psychiatry, Medicine, and Microbiology & Immunology, Medical College of Wisconsin, Milwaukee, WI, United States.
Sridhar RaoDivision of Hematology, Oncology and Marrow Transplant, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, United States.
Fenghuang ZhanMyeloma Center, Department of Internal Medicine and Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
Parameswaran HariDivision of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.
Siegfried JanzDivision of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.

Funding

Defining genetic pathways of plasma-cell neoplasiaR01CA151354 · NCI · UNIVERSITY OF IOWA · PI JANZ, SIEGFRIED · 2010 to 2022
$3.9M
Towards a better understanding of the critical role and therapeutic potential of drug resistant genes in multiple myelomaR01CA236814 · NCI · UNIV OF ARKANSAS FOR MED SCIS · PI FENGHUANG ZHAN · 2020 to 2026
$2.5M
Cohesin Mutations in Acute Myelogenous LeukemiaR01CA204231 · NCI · VERSITI WISCONSIN, INC. · PI RAO, SRIDHAR · 2017 to 2021
$1.9M
NCI NIH HHS R01 CA151354NCI NIH HHS R01 CA204231NCI NIH HHS R01 CA236814
6 · The paper itself

Abstract

Mouse models of human cancer provide an important research tool for elucidating the natural history of neoplastic growth and developing new treatment and prevention approaches. This is particularly true for multiple myeloma (MM), a common and largely incurable neoplasm of post-germinal center, immunoglobulin-producing B lymphocytes, called plasma cells, that reside in the hematopoietic bone marrow (BM) and cause osteolytic lesions and kidney failure among other forms of end-organ damage. The most widely used mouse models used to aid drug and immunotherapy development rely on

Indexed as

AnimalsDisease ProgressionHumansImmunotherapyMiceMonoclonal Gammopathy of Undetermined SignificanceMultiple Myelomaauto- and xenograftinggenetically engineered mouse models of human cancerimmuneimmune pathogenesisimmunodeficient mice modelsMyeloma

Identifiers

PMID34149703
PMCPMC8206561

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.