Evidence map›Paper›PMID 34149699›Full record

ArticleFrontiers in immunology2021

Polymorphisms of Antigen-Presenting Machinery Genes in Non-Small Cell Lung Cancer: Different Impact on Disease Risk and Clinical Parameters in Smokers and Never-Smokers.

Andrzej Wiśniewski, Maciej Sobczyński, Konrad Pawełczyk, Irena Porębska, Monika Jasek, Marta Wagner, Wanda Niepiekło-Miniewska, Aneta Kowal, Joanna Dubis, Natalia Jędruchniewicz and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  4. The Role of Aminopeptidase ERAP1 in Human Pathology-A Review.Current issues in molecular biology · 2024
    Review
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  9. The association ofFrontiers in immunology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Andrzej WiśniewskiLaboratory of Immunogenetics and Tissue Immunology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.
Maciej SobczyńskiDepartment of Bioinformatics and Genomics, Faculty of Biotechnology, University of Wrocław, Wrocław, Poland.
Konrad PawełczykDepartment and Clinic of Thoracic Surgery, Wrocław Medical University, Wrocław, Poland.
Irena PorębskaDepartment of Pulmonology and Lung Oncology, Wrocław Medical University, Wrocław, Poland.
Monika JasekLaboratory of Immunogenetics and Tissue Immunology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.
Marta WagnerLaboratory of Immunogenetics and Tissue Immunology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.
Wanda Niepiekło-MiniewskaLaboratory of Immunogenetics and Tissue Immunology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.
Aneta KowalDepartment of Pulmonology and Lung Oncology, Wrocław Medical University, Wrocław, Poland.
Joanna DubisResearch and Development Centre, Regional Specialist Hospital in Wrocław, Wrocław, Poland.
Natalia JędruchniewiczResearch and Development Centre, Regional Specialist Hospital in Wrocław, Wrocław, Poland.
Piotr KuśnierczykLaboratory of Immunogenetics and Tissue Immunology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.
Ludwik Hirszfeld Institute of Immunology and Experimental Therapy · PLWroclaw Medical University · PLWroclaw Research Centre EIT+ (Poland) · PLPolish Academy of Sciences · PLUniversity of Wrocław · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung cancer is strongly associated with cigarette smoking; nevertheless some never-smokers develop cancer. Immune eradication of cancer cells is dependent on polymorphisms of HLA class I molecules and antigen-processing machinery (APM) components. We have already published highly significant associations of single nucleotide polymorphisms (SNPs) of the

Indexed as

Polymorphism, GeneticAdultAgedAllelesAminopeptidasesAntigen PresentationBiomarkers, TumorCarcinoma, Non-Small-Cell LungFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHaplotypesHumansLung NeoplasmsMaleAminopeptidasesBiomarkers, TumorERAP1 protein, humanERAP2 protein, humanMinor Histocompatibility Antigensantigen-processing machineryERAP1ERAP2geneticsnon-small cell lung cancerPSMB9 (LMP2)smokers versus never-smokers

Identifiers

PMID34149699
PMCPMC8212834
OpenAlexW3167101740

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.