Evidence map›Paper›PMID 34149673›Full record

ArticleFrontiers in microbiology2021

Model Selection Reveals the Butyrate-Producing Gut Bacterium

Remco Kort, Job Schlösser, Alan R Vazquez, Prudence Atukunda, Grace K M Muhoozi, Alex Paul Wacoo, Wilbert F H Sybesma, Ane C Westerberg, Per Ole Iversen, Eric D Schoen

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Review
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  7. Article
  8. Article
  9. Review
  10. Observational
  11. Article
  12. Article
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  14. Review
  15. The butyrate-producing and spore-forming bacterial genusGut microbiome (Cambridge, England) · 2023
    Review
  16. A review of the auditory-gut-brain axis.Frontiers in neuroscience · 2023
    Review
  17. Review
  18. The Bacterial Microbiota of Edible InsectsFoods (Basel, Switzerland) · 2022
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Remco KortDepartment of Molecular Cell Biology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Job SchlösserDepartment of Molecular Cell Biology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Alan R VazquezFaculty of Bioscience Engineering, KU Leuven, Leuven, Belgium.
Prudence AtukundaDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Grace K M MuhooziDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Alex Paul WacooDepartment of Molecular Cell Biology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Wilbert F H SybesmaYoba for Life Foundation, Amsterdam, Netherlands.
Ane C WesterbergInstitute of Health Sciences, Kristiania University College, Oslo, Norway.
Per Ole IversenDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Eric D SchoenFaculty of Bioscience Engineering, KU Leuven, Leuven, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe metabolic activity of the gut microbiota plays a pivotal role in the gut-brain axis through the effects of bacterial metabolites on brain function and development. In this study we investigated the association of gut microbiota composition with language development of 3-year-old rural Ugandan children.

methodsWe studied the language ability in 139 children of 36 months in our controlled maternal education intervention trial to stimulate children's growth and development. The dataset includes 1170 potential predictors, including anthropometric and cognitive parameters at 24 months, 542 composition parameters of the children's gut microbiota at 24 months and 621 of these parameters at 36 months. We applied a novel computationally efficient version of the all-subsets regression methodology and identified predictors of language ability of 36-months-old children scored according to the Bayley Scales of Infant and Toddler Development (BSID-III).

resultsThe best three-term model, selected from more than 266 million models, includes the predictors

conclusionApplication of the all-subsets regression methodology to microbiota data established a correlation between the relative abundance of the anaerobic butyrate-producing gut bacterium

Indexed as

all subsets regressionbutyrateCoprococcus eutactusgut-brain-axislanguage developmentmetagenomic aerotolerant predominance indexmixed integer optimization

Identifiers

PMID34149673
PMCPMC8206532

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.