ArticleFrontiers in microbiology2021
Investigation of Spaceflight Induced Changes to Astronaut Microbiomes.
Article in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Spaceflight-guided pharmacogenomics: a foundational analysis of pharmaceuticals and their responsive gene targets in the space environment.Frontiers in physiology · 2026Pooled it
- Astroimmunology: the effects of spaceflight and its associated stressors on the immune system.Nature reviews. Immunology · 2026Review
- Microbiome dynamics in the congregate environment of U.S. Army Infantry training.Microbiology spectrum · 2026Article
- Review
- Spaceflight Standard Measures is a multidisciplinary study that systematically monitors risks to astronaut health and performance.NPJ microgravity · 2025Review
- The skin microbiome in dermatologic disease.Journal of the American Academy of Dermatology · 2025Review
- Tear Film and Keratitis in Space: Fluid Dynamics and Nanomedicine Strategies for Ocular Protection in Microgravity.Pharmaceutics · 2025Review
- Navigating mental health in space: gut-brain axis and microbiome dynamics.Experimental & molecular medicine · 2025Review
- Circadian Disruption and Sleep Disorders in Astronauts: A Review of Multi-Disciplinary Interventions for Long-Duration Space Missions.International journal of molecular sciences · 2025Review
- Article
- Article
- Space exploration and lifestyle medicine: a narrative review of its implications for astronaut health and remote Earth-based environments.Frontiers in physiology · 2025Review
- Chronobiome medicine: circadian regulation of host-microbiota crosstalk in systemic physiology.Frontiers in endocrinology · 2025Review
- Microbiology of human spaceflight: microbial responses to mechanical forces that impact health and habitat sustainability.Microbiology and molecular biology reviews : MMBR · 2024Review
- Predicting how varying moisture conditions impact the microbiome of dust collected from the International Space Station.Microbiome · 2024Article
- Dermatologic Considerations for Spaceflight and Space Exploration.JID innovations : skin science from molecules to population health · 2024Article
- Longitudinal multi-omics analysis of host microbiome architecture and immune responses during short-term spaceflight.Nature microbiology · 2024Article
- Collection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA).Nature communications · 2024Article
- Spatial multi-omics of human skin reveals KRAS and inflammatory responses to spaceflight.Nature communications · 2024Article
- Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology.Communications medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The International Space Station (ISS) is a uniquely enclosed environment that has been continuously occupied for the last two decades. Throughout its operation, protecting the health of the astronauts on-board has been a high priority. The human microbiome plays a significant role in maintaining human health, and disruptions in the microbiome have been linked to various diseases. To evaluate the effects of spaceflight on the human microbiome, body swabs and saliva samples were collected from four ISS astronauts on consecutive expeditions. Astronaut samples were analyzed using shotgun metagenomic sequencing and microarrays to characterize the microbial biodiversity before, during, and after the astronauts' time onboard the ISS. Samples were evaluated at an individual and population level to identify changes in microbial diversity and abundance. No significant changes in the number or relative abundance of taxa were observed between collection time points when samples from all four astronauts were analyzed together. When the astronauts' saliva samples were analyzed individually, the saliva samples of some astronauts showed significant changes in the relative abundance of taxa during and after spaceflight. The relative abundance of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.