Evidence map›Paper›PMID 34149393›Full record

ArticleFrontiers in aging neuroscience2021

Krüppel-Like Factor 6 Silencing Prevents Oxidative Stress and Neurological Dysfunction Following Intracerebral Hemorrhage

Jia Sun, Jinzhong Cai, Junhui Chen, Siqiaozhi Li, Xin Liao, Yixuan He, Xudong Chen, Sean Hu

Open access · goldAbstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 19 citations in OpenAlex.

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  13. The sirtuin family in health and disease.Signal transduction and targeted therapy · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Jia SunShenzhen Beike Biotechnology Research Institute, Shenzhen, China.
Jinzhong CaiDepartment of Interventional Radiology, Second Clinical Medical College of Jinan University (Shenzhen People's Hospital), Shenzhen, China.
Junhui ChenIntervention and Cell Therapy Center, Shenzhen Hospital of Peking University, Shenzhen, China.
Siqiaozhi LiShenzhen Beike Biotechnology Research Institute, Shenzhen, China.
Xin LiaoShenzhen Beike Biotechnology Research Institute, Shenzhen, China.
Yixuan HeShenzhen Beike Biotechnology Research Institute, Shenzhen, China.
Xudong ChenDepartment of Interventional Radiology, Second Clinical Medical College of Jinan University (Shenzhen People's Hospital), Shenzhen, China.
Sean HuShenzhen Beike Biotechnology Research Institute, Shenzhen, China.
Beike Biotechnology (China) · CNBiotechnology Research Institute · CNJinan University · CNPeking University Shenzhen Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As a severe neurological deficit, intracerebral hemorrhage (ICH) is associated with overwhelming mortality. Subsequent oxidative stress and neurological dysfunction are likely to cause secondary brain injury. Therefore, this study sought to define the role of Krüppel-like factor 6 (KLF6) and underlying mechanism in oxidative stress and neurological dysfunction following ICH. An

Indexed as

HO-1intracerebral hemorrhageKrüppel like factor 6nerve injuryNrf2nuclear transcription factoroxidative stresssirtuin 5

Identifiers

PMID34149393
PMCPMC8209425
OpenAlexW3172740082

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.