Evidence map›Paper›PMID 34149359›Full record

ArticleFrontiers in cellular neuroscience2021

Multimodal Optical Imaging to Investigate Spatiotemporal Changes in Cerebrovascular Function in AUDA Treatment of Acute Ischemic Stroke.

Han-Lin Wang, Jia-Wei Chen, Shih-Hung Yang, Yu-Chun Lo, Han-Chi Pan, Yao-Wen Liang, Ching-Fu Wang, Yi Yang, Yun-Ting Kuo, Yi-Chen Lin and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Cranial and Spinal Window Preparation forExperimental neurobiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Han-Lin WangDepartment of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Jia-Wei ChenDepartment of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Shih-Hung YangDepartment of Mechanical Engineering, National Cheng Kung University, Tainan, Taiwan.
Yu-Chun LoThe Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
Han-Chi PanNational Laboratory Animal Center, Taipei, Taiwan.
Yao-Wen LiangDepartment of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Ching-Fu WangDepartment of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Yi YangDepartment of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Yun-Ting KuoDepartment of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Yi-Chen LinDepartment of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Chin-Yu ChouDepartment of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Sheng-Huang LinDepartment of Neurology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
You-Yin ChenDepartment of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan.
National Yang Ming Chiao Tung University · TWNational Cheng Kung University · TWNational Museum of Marine Biology and Aquarium · TWTaipei Medical University · TWTzu Chi University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Administration of 12-(3-adamantan-1-yl-ureido)-dodecanoic acid (AUDA) has been demonstrated to alleviate infarction following ischemic stroke. Reportedly, the main effect of AUDA is exerting anti-inflammation and neovascularization via the inhibition of soluble epoxide hydrolase. However, the major contribution of this anti-inflammation and neovascularization effect in the acute phase of stroke is not completely elucidated. To investigate the neuroprotective effects of AUDA in acute ischemic stroke, we combined laser speckle contrast imaging and optical intrinsic signal imaging techniques with the implantation of a lab-designed cranial window. Forepaw stimulation was applied to assess the functional changes via measuring cerebral metabolic rate of oxygen (CMRO

Indexed as

AUDAcranial windowischemic strokemultimodal optical imaging systemneovascularizationpenumbra

Identifiers

PMID34149359
PMCPMC8209306
OpenAlexW3173081892

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.