Evidence map›Paper›PMID 34149348›Full record

ArticleFrontiers in neuroscience2021

Temporal Characteristics of Visual Processing in Amblyopia.

Xia Hu, Yi Qin, Xiaoxiao Ying, Junli Yuan, Rong Cui, Xiaowei Ruan, Xianghang He, Zhong-Lin Lu, Fan Lu, Fang Hou

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Amblyopia: progress and promise of functional magnetic resonance imaging.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023
    Pooled it
  2. Article
  3. First-order basis of second-order temporal loss in amblyopia.Journal of translational medicine · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Temporal Contour Integration Deficits in Children With Amblyopia.Investigative ophthalmology & visual science · 2025
    Article
  8. Article
  9. Measuring the Interocular Delay and its Link to Visual Acuity in Amblyopia.Investigative ophthalmology & visual science · 2024
    Article
  10. Article
  11. Decomposing the Response Time in Amblyopia: A Drift Diffusion Model Analysis.Investigative ophthalmology & visual science · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Xia HuSchool of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Yi QinSchool of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Xiaoxiao YingSchool of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Junli YuanSchool of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Rong CuiBiosysen Ltd., Shenzhen, China.
Xiaowei RuanSchool of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Xianghang HeSchool of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Zhong-Lin LuDivision of Arts and Sciences, NYU Shanghai, Shanghai, China.
Fan LuSchool of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Fang HouSchool of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Wenzhou Medical University · CNAffiliated Eye Hospital of Wenzhou Medical College · CNNew York University · US

Funding

The Functions and Mechanisms of Perceptual LearningR01EY017491 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI DOSHER, BARBARA A., LU, ZHONG-LIN · 2006 to 2023
$6.1M
Efficient Assessment of Visual Deficits and Rehabilitation Methods in AmblyopiaR01EY021553 · NEI · OHIO STATE UNIVERSITY · PI LU, ZHONG-LIN · 2012 to 2016
$2.1M
NEI NIH HHS R01 EY017491NEI NIH HHS R01 EY021553
6 · The paper itself

Abstract

purposeAmblyopia affects not only spatial vision but also temporal vision. In this study, we aim to investigate temporal processing deficits in amblyopia.

methodsTwenty amblyopic patients (age: 27.0 ± 5.53 years, 15 males), and 25 normal observers (age: 25.6 ± 4.03 years, 15 males) were recruited in this study. Contrast thresholds in an orientation discrimination task in five target-mask stimulus onset asynchronies (SOA) conditions (16.7 ms, 33.4 ms, 50.0 ms, 83.4 ms, and ∞/no noise) were measured. An elaborated perceptual template model (ePTM) was fit to the behavioral data to derive the temporal profile of visual processing for each participant.

resultsThere were significant threshold differences between the amblyopic and normal eyes [

conclusionAmblyopia is less efficient in processing dynamic visual stimuli. The temporal deficits in amblyopia, represented by a flattened temporal window, are likely independent of spatial vision deficits.

Indexed as

amblyopiacontrast thresholdexternal noiseperceptual template modeltemporal deficitstemporal window

Identifiers

PMID34149348
PMCPMC8211088
OpenAlexW3171053842

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.