Evidence map›Paper›PMID 34149322›Full record

SynthesisJournal of interventional cardiology2021

Safety and Efficacy of High Power Shorter Duration Ablation Guided by Ablation Index or Lesion Size Index in Atrial Fibrillation Ablation: A Systematic Review and Meta-Analysis.

Xing Liu, Chun Gui, Weiming Wen, Yan He, Weiran Dai, Guoqiang Zhong

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Journal of interventional cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Unipolar electrogram-guidedQuantitative imaging in medicine and surgery · 2026
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  11. Acute oesophageal safety and long-term follow-up of AI-guided high-power short-duration with 50 W for atrial fibrillation ablation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xing LiuDepartment of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530000, Guangxi, China.ORCID https://orcid.org/0000-0002-3255-5399
Chun GuiDepartment of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530000, Guangxi, China.ORCID https://orcid.org/0000-0002-5636-4503
Weiming WenDepartment of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530000, Guangxi, China.ORCID https://orcid.org/0000-0001-9003-5263
Yan HeDepartment of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530000, Guangxi, China.ORCID https://orcid.org/0000-0002-2402-0255
Weiran DaiDepartment of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530000, Guangxi, China.ORCID https://orcid.org/0000-0002-0465-2087
Guoqiang ZhongDepartment of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530000, Guangxi, China.ORCID https://orcid.org/0000-0003-0543-0301

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHigh power shorter duration (HPSD) ablation may lead to safe and rapid lesion formation. However, the optimal radio frequency power to achieve the desired ablation index (AI) or lesion size index (LSI) is insubstantial. This analysis aimed to appraise the clinical safety and efficacy of HPSD guided by AI or LSI (HPSD-AI or LSI) in patients with atrial fibrillation (AF).

methodsThe Medline, PubMed, Embase, Web of Science, and the Cochrane Library databases from inception to November 2020 were searched for studies comparing HPSD-AI or LSI and low power longer duration (LPLD) ablation.

resultsSeven trials with 1013 patients were included in the analysis. The analyses verified that HPSD-AI or LSI revealed benefits of first-pass pulmonary vein isolation (PVI) (RR: 1.28; 95% CI: 1.05-1.56, P = 0.01) and acute pulmonary vein reconnection (PVR) (RR: 0.65; 95% CI: 0.48-0.88, P = 0.005) compared with LPLD. HPSD-AI or LSI showed higher freedom from atrial tachyarrhythmia (AT) (RR = 1.32, 95% CI: 1.14-1.53, P = 0.0002) in the subgroup analysis of studies with PVI ± (with or without additional ablation beyond PVI). HPSD-AI or LSI could short procedural time (WMD: -22.81; 95% CI, -35.03 to -10.60, P = 0.0003), ablation time (WMD: -10.80; 95% CI: -13.14 to -8.46, P < .00001), and fluoroscopy time (WMD: -7.71; 95% CI: -13.71 to -1.71, P = 0.01). Major complications and esophageal lesion in HPSD-AI or LSI group were no more than LDLP group (RR: 0.58; 95% CI: 0.20-1.69, P = 0.32) and (RR: 0.84; 95% CI: 0.43-1.61, P = 0.59).

conclusionsHPSD-AI or LSI was efficient for treating AF with shorting procedural, ablation, and fluoroscopy time, higher first-pass PVI, and reducing acute PVR and may increase freedom from AT for patients with additional ablation beyond PVI compared with LPLD. Moreover, complications and esophageal lesion were low and no different between two groups.

Indexed as

Duration of TherapyAtrial FibrillationCatheter AblationFluoroscopyHumansSurgery, Computer-AssistedTreatment Outcome

Identifiers

PMID34149322
PMCPMC8192211

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.