Evidence map›Paper›PMID 34148959›Full record

ArticleInternal medicine (Tokyo, Japan)2021

Development of Myeloperoxidase Anti-neutrophil Cytoplasmic Antibody-positive Necrotizing Crescentic Glomerulonephritis in an Elderly Patient with Immunological Kidney Disease.

Haruyoshi Yoshida, Naoki Takahashi, Takayasu Horiguchi, Hiroki Yasuhara, Tokuharu Tanaka, Yuhao Chen, Toshikazu Takasaki, Hitokazu Tsukao, Michiko Yoshida, Satoshi Kawakami and 5 more

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Haruyoshi YoshidaDepartment of Internal Medicine, Sugita Genpaku Memorial Obama Municipal Hospital, Japan.
Naoki TakahashiDepartment of Nephrology, University of Fukui, Japan.
Takayasu HoriguchiDepartment of Internal Medicine, Sugita Genpaku Memorial Obama Municipal Hospital, Japan.
Hiroki YasuharaDepartment of Internal Medicine, Sugita Genpaku Memorial Obama Municipal Hospital, Japan.
Tokuharu TanakaDepartment of Internal Medicine, Sugita Genpaku Memorial Obama Municipal Hospital, Japan.
Yuhao ChenDepartment of Internal Medicine, Sugita Genpaku Memorial Obama Municipal Hospital, Japan.
Toshikazu TakasakiDepartment of Internal Medicine, Sugita Genpaku Memorial Obama Municipal Hospital, Japan.
Hitokazu TsukaoDepartment of Internal Medicine, Sugita Genpaku Memorial Obama Municipal Hospital, Japan.
Michiko YoshidaDepartment of Internal Medicine, Sugita Genpaku Memorial Obama Municipal Hospital, Japan.
Satoshi KawakamiDepartment of Diagnostic Radiology, Sugita Genpaku Memorial Obama Municipal Hospital, Japan.
Makoto OhtaDepartment of Pathology, Hikone Municipal Hospital, Japan.
Hironobu NaikiDepartment of Molecular Pathology, University of Fukui, Japan.
Satoshi KonishiDepartment of Respiratory Medicine, Kyoto University Hospital, Japan.
Isao ItoDepartment of Respiratory Medicine, Kyoto University Hospital, Japan.
Masayuki IwanoDepartment of Nephrology, University of Fukui, Japan.
University of Fukui · JPKyoto University Hospital · JPHikone Central Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 78-year-old man presented with hypercalcemia and renal disease with high serum IgG4 and positive myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA), exhibiting sarcoidosis-like chest findings. A renal biopsy revealed tubulointerstitial nephritis, membranous nephropathy (MN), and sub-capsular lymphoid aggregates without fulfilling the diagnostic criteria of IgG4-related disease or sarcoidosis. Steroid therapy ameliorated the serological and renal abnormalities. After 5 years, following gradual increases in the neutrophil count and upper respiratory infection (URI), necrotizing crescentic glomerulonephritis (NCGN) developed with an increased serum MPO-ANCA level. These results suggest that in the presence of MPO-ANCA in immune senescence, the persistent neutrophil increase with URI may lead to the development of NCGN.

Indexed as

GlomerulonephritisGlomerulonephritis, MembranousAgedAntibodies, Antineutrophil CytoplasmicHumansKidneyMalePeroxidaseAntibodies, Antineutrophil CytoplasmicPeroxidasehypercalcemiaIgG4-RKDimmune senescencelymphoid aggregatesmembranous nephropathysarcoidosis

Identifiers

PMID34148959
PMCPMC8758455
OpenAlexW3173600153

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.