Evidence map›Paper›PMID 34148945›Full record

ArticleInternal medicine (Tokyo, Japan)2021

Treatment Outcome of Nab-paclitaxel Plus Gemcitabine for Leptomeningeal Carcinomatosis from Pancreatic Ductal Adenocarcinoma: An Autopsy Case Report.

Kunio Iwatsuka, Daiichiro Kikuta, Hitoshi Shibuya, Masahiro Ogawa, Takuji Gotoda, Mitsuhiko Moriyama, Hiroshi Nakagawara, Akihiro Hemmi, Kenji Yamao

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Kunio IwatsukaDivision of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine Graduate School of Medicine, Japan.
Daiichiro KikutaDivision of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine Graduate School of Medicine, Japan.
Hitoshi ShibuyaDivision of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine Graduate School of Medicine, Japan.
Masahiro OgawaDivision of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine Graduate School of Medicine, Japan.
Takuji GotodaDivision of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine Graduate School of Medicine, Japan.
Mitsuhiko MoriyamaDivision of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine Graduate School of Medicine, Japan.
Hiroshi NakagawaraDivision of Gastroenterology, Yokohama Chuo Hospital, Japan.
Akihiro HemmiDivision of Pathology, Nihon University School of Medicine Graduate School of Medicine, Japan.
Kenji YamaoDepartment of Gastroenterology, Narita Memorial Hospital, Japan.
Nihon University · JPGunma Chuo Hospital · JPJapanese Red Cross Narita Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 57-year-old woman with a sudden-onset seizure was hospitalized. Brain magnetic resonance imaging findings led to a suspicion of leptomeningeal carcinomatosis (LMC) without a brain parenchymal tumor, and abdominal computed tomography showed a tumor in the pancreatic tail. Endoscopic ultrasonography-guided fine needle aspiration of the pancreatic mass revealed adenocarcinoma. Therefore, LMC from pancreatic ductal adenocarcinoma was strongly suspected. She received three courses of nab-paclitaxel plus gemcitabine and whole-brain radiation. Shortly thereafter, she developed a severe consciousness impediment and died. A pathological autopsy showed adenocarcinoma in a wide area of the leptomeninges.

Indexed as

AdenocarcinomaMeningeal CarcinomatosisPancreatic NeoplasmsAlbuminsAntineoplastic Combined Chemotherapy ProtocolsAutopsyDeoxycytidineFemaleGemcitabineHumansMiddle AgedPaclitaxelTreatment Outcome130-nm albumin-bound paclitaxelAlbuminsDeoxycytidineGemcitabinePaclitaxelchemotherapyleptomeningeal carcinomatosispancreatic ductal adenocarcinomaradiation therapy

Identifiers

PMID34148945
PMCPMC8710377
OpenAlexW3174603681

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.