Evidence map›Paper›PMID 34148891›Full record

ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2021

RNA methylation and neurovascular unit remodeling.

Xinyi Lü, Yishu Fan, Shuntong Kang, Bo Xiao, Mengqi Zhang

Open access · greenAbstract read
In one paragraph

Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Xinyi LüDepartment of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China. lvxinyi1368@163.com.
Yishu FanDepartment of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.
Shuntong KangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.
Bo XiaoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.
Mengqi ZhangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China. zhangmengqi8912@163.com.
Central South University · CNXiangya Hospital Central South University · CN

Funding

the Key Research and Development Program of Hunan Province 2020SK2063the National Natural Science Foundation 81501025the Natural Science Foundation of Hunan Province 2020JJ4134
6 · The paper itself

Abstract

RNA methylation is of great significance in the regulation of gene expression, among which the more important methylation modifiers are N6-methyladenosine (m6A) and 5-methylcytosine (m5C). The methylation process is mainly regulated by 3 kinds of proteins: methyltransferase, demethylase, and reader. m6A, m5C, and their related proteins have high abundance in the brain, and they have important roles in the development of the nervous system and the repair and remodeling of the vascular system. The neurovascular unit (NVU) is a unit of brain structure and function composed of neurons, capillaries, astrocytes, supporting cells, and extracellular matrix. The local microenvironment for NVU has an important role in nerve cell function repair, and the remodeling of NVU is of great significance in the prognosis of various neurological diseases.

Indexed as

AdenosineMethyltransferases5-MethylcytosineMethylationRNA5-MethylcytosineAdenosineMethyltransferasesRNA5-methylcytosineblood vesselN6-methyladenosineneuronneurovascular unitRNA methylation

Identifiers

PMID34148891
PMCPMC10930208
OpenAlexW3175492181

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.