Evidence map›Paper›PMID 34148869›Full record

ArticleBiomolecules & therapeutics2021

Hair Growth Promotion by δ-Opioid Receptor Activation.

Mei Zheng, Nahyun Choi, Gianfranco Balboni, Ying Xia, Jong-Hyuk Sung

Open access · hybridAbstract read
In one paragraph

Article in Biomolecules & therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Mei ZhengSTEMORE Co. Ltd., Incheon 21983, Republic of Korea.
Nahyun ChoiSTEMORE Co. Ltd., Incheon 21983, Republic of Korea.
Gianfranco BalboniDepartment of Life and Environment Sciences, University of Cagliari, Cagliari 09124, Italy.
Ying XiaShanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function, Fudan University, Shanghai 200032, China.
Jong-Hyuk SungSTEMORE Co. Ltd., Incheon 21983, Republic of Korea.
Fudan University · CNUniversity of Cagliari · ITYonsei University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Literature has revealed that the delta opioid receptor (DOR) exhibited diverse pharmacological effects on neuron and skin. In the present study, we have investigated whether the activation of DOR has hair-growth promotion effects. Compared with other opioid receptor, DOR was highly expressed in epidermal component of hair follicle in human and rodents. The expression of DOR was high in the anagen phase, but it was low in the catagen and telogen phases during mouse hair cycle. Topical application of UFP-512, a specific DOR agonist, significantly accelerated the induction of the anagen in C

Indexed as

AnagenHair growthOuter root sheath cellsUFP-512Wnt/β-cateninδ-opioid receptor

Identifiers

PMID34148869
PMCPMC8551727
OpenAlexW3173806140

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.