Evidence map›Paper›PMID 34148472›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2021

Identification of a novel SPT inhibitor WXP-003 by docking-based virtual screening and investigation of its anti-fungi effect.

Xin Wang, Xin Yang, Xin Sun, Yi Qian, Mengyao Fan, Zhehao Zhang, Kaiyuan Deng, Zaixiang Lou, Zejun Pei, Jingyu Zhu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Cell-Wall-Degrading Enzymes-Related Genes Originating fromInternational journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Xin WangThe Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University, Wuxi, China.
Xin YangThe Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University, Wuxi, China.
Xin SunThe Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University, Wuxi, China.
Yi QianThe Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University, Wuxi, China.
Mengyao FanThe Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University, Wuxi, China.
Zhehao ZhangThe Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University, Wuxi, China.
Kaiyuan DengThe Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University, Wuxi, China.
Zaixiang LouSchool of Food Science and Technology, Jiangnan University, Wuxi, China.
Zejun PeiThe Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University, Wuxi, China.
Jingyu ZhuSchool of Pharmaceutical Sciences, Jiangnan University, Wuxi, China.
Nanjing Medical University · CNJiangnan University · CNWuxi No.2 People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serine palmitoyltransferase (SPT) plays the key role on catalysing the formation of 3-ketodihydrosphingosine, which is the first step of the

Indexed as

AnimalsAntifungal AgentsEnzyme InhibitorsHumansMiceMolecular Docking SimulationSerine C-PalmitoyltransferaseAntifungal AgentsEnzyme InhibitorsSerine C-Palmitoyltransferaseanti-fungiinhibitorSPTVirtual screening

Identifiers

PMID34148472
PMCPMC8218698
OpenAlexW3177099785

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.