SynthesisHypertension (Dallas, Tex. : 1979)2021
Blood-Brain Barrier Crossing Renin-Angiotensin Drugs and Cognition in the Elderly: A Meta-Analysis.
Open access · bronzeAbstract readMeta-Analysis
In one paragraph
Synthesis in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 2 pooled it
10.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 2 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- The relationship between renin-angiotensin system-modulating medication and depression: a systematic review.Translational psychiatry · 2026Pooled it
- Renin-angiotensin system inhibitor use and risk of Parkinson's disease: a meta-analysis.Acta neurologica Belgica · 2025Pooled it
- Effect of renin-angiotensin system antihypertensive medication use on cognitive function in diabetes mellitus with obesity or overweight: An ancillary study to the Action for Health in Diabetes (Look AHEAD) trial.Diabetes, obesity & metabolism · 2022Trial
- Cerebral blood flow in conscious rats and implications for therapeutic interventions.Experimental physiology · 2026Review
- The choroid plexus is a source of active renin in the central nervous system.Research square · 2026Article
- The association between cognitive function trajectories and all-cause mortality in middle-aged and older Chinese adults with cardiovascular disease: A longitudinal study from CHARLS.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Impact of Prior Angiotensin-Converting Enzyme Inhibitor and Angiotensin II Receptor Blocker Use on Delirium Incidence in ICU Patients: A Retrospective Study.Health science reports · 2026Article
- Captopril restores microglial homeostasis and reverses ASD-like phenotype in a model of ASD induced by exposure in utero to anti-caspr2 IgG.Molecular psychiatry · 2026Article
- Neuro-renin-angiotensin-aldosterone system axis in alzheimer's disease: from molecular dysregulation to therapeutic redirection.Metabolic brain disease · 2026Review
- The Japanese Society of Hypertension Guidelines for the management of elevated blood pressure and hypertension 2025 (JSH2025).Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Effect of 6-methyl-5-hepten-2-one (Sulcatone) on hemostasis parameters in SHR rats: In Silico, In Vitro, and In Vivo approaches.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- A comparison of drugs targeting the renin-angiotensin system and global cognition in aging.Journal of Alzheimer's disease : JAD · 2025Article
- Factors associated with motor manifestations in older adults with Alzheimer's dementia: a cross-sectional analysis.European geriatric medicine · 2025Article
- Unlocking Novel Therapeutic Potential of Angiotensin II Receptor Blockers.International journal of molecular sciences · 2025Review
- Acute radiation-induced brain injury in patients with glioma and the construction of a clinical prediction model: a cohort study.Translational cancer research · 2025Article
- Immunomodulatory Effects of RAAS Inhibitors: Beyond Hypertension and Heart Failure.Biomedicines · 2025Review
- Peripheral Leukocyte Syndecan-3 Is Elevated in Alzheimer's Disease: Evidence from a Human Study.International journal of molecular sciences · 2025Article
- Telmisartan is neuroprotective in a hiPSC-derived spinal microtissue model for C9orf72 ALS via inhibition of neuroinflammation.Stem cell reports · 2025Article
- The Use of Antihypertensive Medication and In Vivo Alzheimer's Disease Pathology.Annals of neurology · 2025Article
- Blood pressure and the brain: the conundrum of hypertension and dementia.Cardiovascular research · 2025Review
Corrections and comments
- Commented on by
Authors and funding
14 authors at 10 institutions in 6 countries.
Jean K HoInstitute for Memory Impairments and Neurological Disorders (J.K.H., D.A.N.), University of California, Irvine.
Frank MoriartySchool of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin (F.M.).
Jennifer J ManlyDepartment of Neurology, Gertrude H. Sergievsky Center, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York (J.J.M.).
Eric B LarsonKaiser Permanente Washington Health Research Institute, Seattle, WA (E.B.L.).
Denis A EvansDepartment of Internal Medicine, Rush University Medical Center, Chicago, IL (D.A.E., K.B.R.).
Kumar B RajanDepartment of Internal Medicine, Rush University Medical Center, Chicago, IL (D.A.E., K.B.R.).
Elizabeth M HudakDepartment of Psychiatry and Behavioral Neurosciences, University of South Florida, Tampa (E.M.H.).
Lamiaa HassanInstitute of Medical Epidemiology, Biometrics and Informatics, Interdisciplinary Center for Health Sciences, Martin-Luther-University Halle-Wittenberg, Halle/Saale, Saxony-Anhalt, Germany (L.H.).
Enwu LiuMary MacKillop Institute for Health Research, Australian Catholic University (E.L.).
Nobuyuki SatoDepartment of Cardiovascular Medicine, Asahikawa Medical University, Japan (N.S., N.H.).
Naoyuki HasebeDepartment of Cardiovascular Medicine, Asahikawa Medical University, Japan (N.S., N.H.).
Danielle LaurinCentre d'excellence sur le vieillissement de Québec, Centre de recherche du CHU de Québec and VITAM-Centre de recherche en santé durable, Canada (D.L., P-H.C.).
Pierre-Hugues CarmichaelCentre d'excellence sur le vieillissement de Québec, Centre de recherche du CHU de Québec and VITAM-Centre de recherche en santé durable, Canada (D.L., P-H.C.).
Daniel A NationInstitute for Memory Impairments and Neurological Disorders (J.K.H., D.A.N.), University of California, Irvine.
Asahikawa Medical University · JPInstitut Universitaire en Santé Mentale de Québec · CARush University Medical Center · USUniversity of California, Irvine · USAlzheimer’s Disease Neuroimaging Initiative · USAustralian Catholic University · AUKaiser Permanente Washington Health Research Institute · USMartin Luther University Halle-Wittenberg · DERoyal College of Surgeons in Ireland · IEUniversity of South Florida · US
Funding
VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0MNATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8MTHERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI GRABOWSKI, THOMAS J. · 1985 to 2019
$57.2MSUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI LEURGANS, SUE E. · 1991 to 2020
$49.1MFurthering scientific understanding of mechanisms underlying resilience to the effects of AD pathology by incorporating state of the art quantification of gliosis, inflammation, & synaptic toxicityU01AG006781 · NIA · UNIVERSITY OF WASHINGTON · PI CRANE, PAUL K, LARSON, ERIC B · 1986 to 2020
$39.3MResearch Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3MUC Irvine Alzheimer's Disease Research Center Induced Pluripotent Stem Cell CoreP50AG016573 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI LAFERLA, FRANK M · 2000 to 2019
$37.0MVascular Contributions to Dementia and Genetic Risk Factors for Alzheimer's DiseaseP01AG052350 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation, ARTHUR W TOGA · 2016 to 2026
$28.4MRisk Factors for Incident Alzheimer's Disease in a Biracial CommunityR01AG011101 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI EVANS, DENIS A · 1993 to 2010
$24.7MINDIANAPOLIS/IBADAN DEMENTIA PROJECTR01AG009956 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI HALL, KATHLEEN S · 1991 to 2010
$14.0MVITAMIN D NUTRITION IN THE INSTITUTIONALIZED ELDERLYP01AG004390 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI CHENG, DEBBIE M. · 1985 to 2008
$13.2MREGARDS - MI StudyR01HL080477 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LEVITAN, EMILY B, SAFFORD, MONIKA M · 2006 to 2020
$11.6MNHLBI NIH HHS R01 HL080477NHLBI NIH HHS T32 HL007594NIA NIH HHS P01 AG004390NIA NIH HHS P01 AG052350NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG010161NIA NIH HHS P50 AG005136NIA NIH HHS P50 AG016573NIA NIH HHS R01 AG009956NIA NIH HHS R01 AG011101NIA NIH HHS R01 AG019181NIA NIH HHS R01 AG060049NIA NIH HHS R01 AG064228NIA NIH HHS R37 AG005739NIA NIH HHS U01 AG006781NIA NIH HHS U01 AG016976NIMH NIH HHS R24 MH080827NINDS NIH HHS U01 NS041588
Abstract
[Figure: see text].
Indexed as
AgedAntihypertensive AgentsBlood-Brain BarrierBlood PressureCognitionHumansHypertensionRenin-Angiotensin SystemAntihypertensive Agentsangiotensin converting enzyme inhibitorsangiotensin receptor blockersblood-brain barriercognitiondementiahypertensionrenin-angiotensin system
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.