Evidence map›Paper›PMID 34148163›Full record

ArticleJournal of neuro-oncology2021

Implantation of Carmustine wafers after resection of malignant glioma with and without opening of the ventricular system.

Christoph Bettag, Abdelhalim Hussein, Alexandra Sachkova, Hans Christoph Bock, Dorothee Mielke, Veit Rohde, Tammam Abboud

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In one paragraph

Article in Journal of neuro-oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Observational
  4. Article
  5. Intraoperative MR Imaging during Glioma Resection.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Christoph BettagDepartment of Neurosurgery, University Medical Center Goettingen, University Hospital Göttingen, Georg-August-University, Goettingen, Germany.
Abdelhalim HusseinDepartment of Neurosurgery, University Medical Center Goettingen, University Hospital Göttingen, Georg-August-University, Goettingen, Germany.
Alexandra SachkovaDepartment of Neurosurgery, University Medical Center Goettingen, University Hospital Göttingen, Georg-August-University, Goettingen, Germany.
Hans Christoph BockDepartment of Neurosurgery, University Medical Center Goettingen, University Hospital Göttingen, Georg-August-University, Goettingen, Germany.
Dorothee MielkeDepartment of Neurosurgery, University Medical Center Goettingen, University Hospital Göttingen, Georg-August-University, Goettingen, Germany.
Veit RohdeDepartment of Neurosurgery, University Medical Center Goettingen, University Hospital Göttingen, Georg-August-University, Goettingen, Germany.
Tammam AbboudDepartment of Neurosurgery, University Medical Center Goettingen, University Hospital Göttingen, Georg-August-University, Goettingen, Germany. tammam.abboud@med.uni-goettingen.de.ORCID http://orcid.org/0000-0003-4379-6961
University of Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveImplantation of biodegradable Carmustine wafers in patients with malignant glioma is not generally recommended when the ventricular system is opened during tumor resection. Thrombin/fibrinogenn-covered collagen fleeces showed promising results in sufficiently closing ventricular defects. The aim of this study was to evaluate the postoperative morbidity in patients with implanted Carmustine wafers either with opened or intact ventricular system.

methodsA consecutive series of patients who underwent resection of malignant glioma with implantation of Carmustine wafers was analyzed. In case of opening of the ventricular system, the defect in the ventricle wall was sealed using a collagen sponge coated with fibrinogen and thrombin prior to the implantation of the wafers. Postoperative adverse events (AE) and Karnofsky performance status scale (KPS) at follow up were compared between both groups.

resultsFifty-four patients were included. The ventricular system was opened in 33 patients and remained intact in 21 patients. Both groups were comparable in terms of age, rate of primary and recurrent glioma, preoperative KPS, rate of gross total resection and number of implanted wafers. Postoperative AEs occurred in 9/33 patients (27.3%) with opened and in 5/21 patients (23.8%) with intact ventricular system (p = 0.13). At follow-up assessments, KPS was not significantly different between both groups (p = 0.18). Opened ventricular system was not associated with a higher incidence of postoperative AEs (p = 0.98).

conclusionAppropriate closure of opened ventricular system during resection of malignant glioma allows for a safe implantation of Carmustine wafers and is not associated with a higher incidence of postoperative AEs.

Indexed as

Brain NeoplasmsGliomaAntineoplastic Agents, AlkylatingCarmustineDrug ImplantsHumansNeoplasm Recurrence, LocalRetrospective StudiesThrombinAntineoplastic Agents, AlkylatingCarmustineDrug ImplantsThrombinCarmustine waferLocal brain tumor therapyMalignant gliomaVentricular system

Identifiers

PMID34148163
OpenAlexW3175501113

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.