Evidence map›Paper›PMID 34148065›Full record

ArticleModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2021

Clinicopathologic and prognostic features of TdT-negative pediatric B-lymphoblastic leukemia.

Matthew M Klairmont, Yinmei Zhou, Cheng Cheng, Ching-Hon Pui, Sima Jeha, Tanja A Gruber, Yiwei Liu, Hiroto Inaba, John Kim Choi

Open access · bronzeAbstract read
In one paragraph

Article in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Matthew M KlairmontDepartment of Pathology, New York University School of Medicine, New York, NY, USA.
Yinmei ZhouDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Cheng ChengDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Ching-Hon PuiDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-0303-5658
Sima JehaDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Tanja A GruberDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Yiwei LiuDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.
Hiroto Inaba *Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
John Kim Choi *Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA. johnchoi@uabmc.edu.ORCID 0000-0002-2861-0180
St. Jude Children's Research Hospital · USStanford University · US

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
NCI NIH HHS P30 CA021765
6 · The paper itself

Abstract

Little is known about B-lymphoblastic leukemia (B-ALL) that lacks expression of terminal deoxynucleotidyl transferase (TdT). To address this, we performed the largest study to date of TdT-negative B-ALL using data from St. Jude Total XV and XVI clinical trials. Compared to TdT-positive B-ALL (n = 896), TdT-negative B-ALL (n = 21) was associated with younger age (median, 1.4 versus 6.8 years, P < 0.001), higher white blood cell count (median, 52.8 versus 9.9 × 10

Indexed as

AdolescentBiomarkers, TumorChildChild, PreschoolCytogeneticsDisease-Free SurvivalDNA NucleotidylexotransferaseFemaleFlow CytometryGene RearrangementHistone-Lysine N-MethyltransferaseHumansImmunophenotypingInfantLeukocyte CountMaleBiomarkers, TumorDNA NucleotidylexotransferaseHistone-Lysine N-MethyltransferaseKMT2A protein, humanMLLT1 protein, humanMyeloid-Lymphoid Leukemia ProteinNeoplasm ProteinsNuclear ProteinsTranscription Factors

Identifiers

PMID34148065
PMCPMC9770053
OpenAlexW3175535074

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.