Evidence map›Paper›PMID 34148057›Full record

ArticleCell death & disease2021

Mitochondrial Ca

Zhengying Yu, Haipeng Wang, Wanyi Tang, Shaoyang Wang, Xiaoying Tian, Yujie Zhu, Hao He

Open access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Mitochondrial pearling: membrane biophysics, CaFrontiers in cell and developmental biology · 2026
    Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Targeting mitochondrial CaThe Journal of physiology · 2024
    Review
  13. Article
  14. Activation of CaCell death and differentiation · 2024
    Article
  15. The mitochondrial CaScientific reports · 2022
    Article
  16. Review
  17. Activation of Mitochondrial CaBio-protocol · 2022
    Article
  18. Mitochondrial autophagy in the sleeping brain.Frontiers in cell and developmental biology · 2022
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Zhengying YuSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Haipeng WangSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Wanyi TangSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Shaoyang WangSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Xiaoying TianSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Yujie ZhuDepartment of Dermatology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. zyjfd@163.com.
Hao HeSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China. haohe@sjtu.edu.cn.ORCID 0000-0003-0832-8310
Shanghai Jiao Tong University · CN

Funding

National Natural Science Foundation of China (National Science Foundation of China) 92054105, 62022056, and 61975118
6 · The paper itself

Abstract

Dysregulation of the PINK1/Parkin-mediated mitophagy is essential to Parkinson's disease. Although important progress has been made in previous researches, the biochemical reagents that induce global and significant mitochondrial damage may still hinder deeper insights into the mechanisms of mitophagy. The origin of PINK1/Parkin pathway activation in mitophagy remains elusive. In this study, we develop an optical method, ultra-precise laser stimulation (UPLaS) that delivers a precise and noninvasive stimulation onto a submicron region in a single mitochondrial tubular structure. UPLaS excites localized mitochondrial Ca

Indexed as

Calcium SignalingMitophagyCalciumHeLa CellsHumansMembrane Potential, MitochondrialMicroscopy, ConfocalMicroscopy, FluorescenceMitochondriaProtein KinasesPTEN-Induced Putative KinaseReactive Oxygen SpeciesSingle-Cell AnalysisTime FactorsTime-Lapse ImagingUbiquitin-Protein LigasesCalciumparkin proteinProtein KinasesPTEN-Induced Putative KinaseReactive Oxygen SpeciesUbiquitin-Protein Ligases

Identifiers

PMID34148057
PMCPMC8214625
OpenAlexW3176772097

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.